acetylatorn.
/əˈsɛtᵻleɪtə/, U.S. /əˈsɛdlˌeɪdər/ Pharmacology and Physiology.
A person or animal in whom a drug or other substance is acetylated (and hence inactivated), esp. at a specified (slow or fast) rate.
ΚΠ
1961 Jrnl. Chronic Dis. 14 19 In studying isoniazid metabolism in man... The level of free INH in the plasma 6 hours after administration proved a satisfactory basis of classification of the subject as either a rapid inactivator (i.e. rapid acetylator) or a slow inactivator.
1973 Gut 12 631 The metabolism of salicylazosulphapyridine was studied in 16 patients with ulcerative colitis admitted to hospital. The acetylator phenotype was determined on admission.
1992 Independent 27 Oct. 13/5 To their relief, while the controls fell equally into slow and fast acetylators, an amazing 10 out of 11 cancer patients fell into the slow category.
1998 Canad. Jrnl. Physiol. & Pharmacol. 76 701 There was..no difference in the total urine amantadine excreted over 8 h between acetylators and nonacetylators.
This entry has been updated (OED Third Edition, September 2009; most recently modified version published online December 2021).
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