With of or to. Without consideration of or regard to; irrespective of, regardless of. Also with following interrogative clause. Cf. regardless, adv.…

Without regard to or consideration of other things or of (†to) something specified; independently.

In an independent manner; without dependence on another person or thing, or on each other; apart from or without regard to the action of others.

Now chiefly in adverbial construction, qualifying a verb expressed or understood; = irrespectively, adv. Const. of.

= regardless, adv. 1. Cf. irrespective, adj. adv.3b.

= irrespectively, adv. 3. Cf. unrespective, adv.