In a statement, discourse, or argument, where points or topics are enumerated: in the first place, as the first thing to be mentioned or…

Before something else, in the first place. Obsolete.

In the first place; first. Originally used to introduce the first of a number of items, as in an inventory or will; thence in more general use…

In the first place, firstly, on the one hand. Obsolete.

Primarily, principally. Obsolete.

In the first place, in the highest degree; firstly, primarily, originally.

in the first instance: as the first step in proceeding; in the first place.

for one thing: as one point to be noted; in the first place. Similarly for another thing.