With verbs of grieving, annoying, etc.: So as to cause mental pain or irritation; deeply, intensely.

So as to be a cause for sorrow or pity; grievously, lamentably.

In a dreary manner: see the adjective.

In a way that causes or is accompanied by mental or physical pain; distressingly.

In a manner involving mental pain, distress, or dissatisfaction.

So as to cause pain, danger, disgrace, or harm of any kind; cruelly, unkindly, dangerously… With neutral verbs such as use, treat, behave.

In an afflictive manner; so as to distress; painfully, grievously, troublesomely.

In an afflicting manner; so as to distress or trouble.

In a way that beats strongly or distressingly on the mind or feelings.