an enzyme that acts as a catalyst in the formation of a cyclic compound
cyclase in American English
(ˈsaikleis, -kleiz)
noun
Biochemistry
an enzyme, as adenyl cyclase, that catalyzes the formation of a cyclic compound
Word origin
[1940–45; cycl(ic) + -ase]This word is first recorded in the period 1940–45. Other words that entered Englishat around the same time include: black box, sealant, snorkel, update, zap-ase is a suffix used in the names of enzymes. Other words that use the affix -ase include: amylase, ligase, peroxidase, transferase, zymase
Examples of 'cyclase' in a sentence
cyclase
However, the anti-apoptotic effect of cilostazol was not reversed by an inhibitor of adenylyl cyclase.
Youn Ju Lee, Mi-Sun Shu, Jong-Yeon Kim, Yun-Hye Kim, Kyeong Hwa Sim, Woo Jung Sung,Jong Ryeol Eun 2019, 'Cilostazol protects hepatocytes against alcohol-induced apoptosis via activation ofAMPK pathway', PLOS ONE10.1371/journal.pone.0211415. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These receptors may act antagonistically on adenylate cyclase.
Jiangnan Luo, Oleh V Lushchak, Philip Goergen, Michael J Williams, Dick R Nässel 2014, 'Drosophila insulin-producing cells are differentially modulated by serotonin and octopaminereceptors and affect social behavior.', PLoS ONEhttp://europepmc.org/articles/PMC4055686?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Several bacterial pathogens produce nucleotidyl cyclase toxins to manipulate eukaryotic host cells.
Dorothée Raoux-Barbot, Alexander Belyy, Lina Worpenberg, Sabrina Montluc, Celia Deville,Véronique Henriot, Christophe Velours, Daniel Ladant, Louis Renault, Undine Mechold 2018, 'Differential regulation of actin-activated nucleotidyl cyclase virulence factors byfilamentous and globular actin.', PLoS ONEhttp://europepmc.org/articles/PMC6231621?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These receptors are coupled to adenylyl cyclase, calcium mobilization and ion channel activation.
Crittenden Elizabeth L, González Alfredo, García Dana M 2004, 'Activation of muscarinic acetylcholine receptors elicits pigment granule dispersionin retinal pigment epithelium isolated from bluegill', BMC Neurosciencehttp://www.biomedcentral.com/1471-2202/5/23. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Plastoglobules and triacylglycerol micelles were the most efficient reaction environment for the cyclase.
Jolanta Dłużewska, Renata Szymańska, Michal Gabruk, Peter B. Kós, Beatrycze Nowicka,Jerzy Kruk 2016, 'Tocopherol Cyclases—Substrate Specificity and Phylogenetic Relations', PLOS ONE10.1371/journal.pone.0159629. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Absorption of a photon inhibits the cyclase activity, most likely by inhibiting the phosphoryl transfer.
Yuehui Tian, Shiqiang Gao, Eva Laura von der Heyde, Armin Hallmann, Georg Nagel 2018, 'Two-component cyclase opsins of green algae are ATP-dependent and light-inhibitedguanylyl cyclases', BMC Biologyhttp://link.springer.com/article/10.1186/s12915-018-0613-5. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Yan 7874 did not produce any specific adenylyl cyclase response.
Ainoleena Turku, Maiju K. Rinne, Gustav Boije af Gennäs, Henri Xhaard, Dan Lindholm,Jyrki P. Kukkonen 2017, 'Orexin receptor agonist Yan 7874 is a weak agonist of orexin/hypocretin receptorsand shows orexin receptor-independent cytotoxicity', PLOS ONE10.1371/journal.pone.0178526. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In mammalian cells nine membrane-associated and one soluble adenylyl cyclase isoforms occur.
Krzysztof Pociecha, Katarzyna Przejczowska-Pomierny, Agnieszka Cios, Elżbieta Wyska 2015, 'Contemporary concepts in studies on cyclic AMP and its role in the inflammatory reaction',Postępy Higieny i Medycyny Doświadczalnejhttp://phmd.pl/gicid/01.3001.0009.6550. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)