having a harmful effect on the organs or nerves concerned with hearing and balance
Derived forms
ototoxicity (ˌoutətɑkˈsɪsɪti)
noun
Word origin
[1950–55; oto- + toxic]This word is first recorded in the period 1950–55. Other words that entered Englishat around the same time include: conflict of interest, drip-dry, hot line, point-of-sale, wiretap
Examples of 'ototoxic' in a sentence
ototoxic
A few studies suggest that the effect of noise may be enhanced by ototoxic chemicals.
Yoon-Hyeong Choi, KyooSang Kim 2014, 'Noise-induced hearing loss in Korean workers: co-exposure to organic solvents andheavy metals in nationwide industries.', PLoS ONEhttp://europepmc.org/articles/PMC4037174?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Sensorineural hearing loss was a consequence of using ototoxic medications.
Babac Snežana, Petrović-Lazić Mirjana, Tatović Milica, Stojanović-Kamberović Vesna,Ivanković Zoran 2010, 'Otoacoustic emissions in hearing screening in children', Vojnosanitetski Pregledhttp://www.doiserbia.nb.rs/img/doi/0042-8450/2010/0042-84501005379B.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The ototoxic effects of radiotherapy have been poorly characterized.
Amber Khan, Amy Budnick, Dana Barnea, Darren R. Feldman, Kevin C. Oeffinger, EmilyS. Tonorezos 2018, 'Hearing Loss in Adult Survivors of Childhood Cancer Treated with Radiotherapy', Childrenhttp://www.mdpi.com/2227-9067/5/5/59. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
High concentration of streptomycin could lead to ototoxic and nephrotoxic effects.
Monica Cristina Cara,, Gheorghita Simion,, Panfiloiu Mirabela,, Harieta Pirlea 2011, 'Monitoring antibiotic residues in honey', Medicamentul Veterinarhttp://www.veterinarypharmacon.com/docs/997-2011-ART.%2010.%20eng..pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Proteomic analysis also detected clear differences in protein expression when ototoxic medications were introduced.
Eugene H. C. Wong, You Yi Dong, Mali Coray, Maurizio Cortada, Soledad Levano, AlexanderSchmidt, Yves Brand, Daniel Bodmer, Laurent Muller 2018, 'Inner ear exosomes and their potential use as biomarkers', PLOS ONE10.1371/journal.pone.0198029. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, other chemicals such as heavy metals have been also identified as ototoxic agents.
Marie-Josée Castellanos, Adrian Fuente 2016, 'The Adverse Effects of Heavy Metals with and without Noise Exposure on the Human Peripheraland Central Auditory System: A Literature Review', International Journal of Environmental Research and Public Healthhttp://www.mdpi.com/1660-4601/13/12/1223. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Loss of hair cells after exposure to ototoxic agents causes hearing loss.
Azadeh Jadali, Azadeh Jadali, Azadeh Jadali, Yu-Lan M. Ying, Kelvin Y. Kwan, KelvinY. Kwan 2017, 'Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival', Frontiers in Cellular Neurosciencehttp://journal.frontiersin.org/article/10.3389/fncel.2017.00137/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The sensory hair cells of the inner ear are exquisitely sensitive to ototoxic insults.
Azadeh Jadali, Azadeh Jadali, Azadeh Jadali, Yu-Lan M. Ying, Kelvin Y. Kwan, KelvinY. Kwan 2017, 'Activation of CHK1 in Supporting Cells Indirectly Promotes Hair Cell Survival', Frontiers in Cellular Neurosciencehttp://journal.frontiersin.org/article/10.3389/fncel.2017.00137/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ototoxic hearing loss was noted in 27 participants (52%) in 1 month post-treatment.
Delicia Appana, Lavanithum Joseph, Jessica Paken 2016, 'An audiological profile of patients infected with multi-drug resistant tuberculosisat a district hospital in KwaZulu-Natal', South African Journal of Communication Disordershttps://sajcd.org.za/index.php/sajcd/article/view/154. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Cisplatin's ototoxic effects are multifaceted, culminating in irreversible damage to the mechanosensory hair cells in the inner ear.
Jonathon W. Vargo, Steven N. Walker, Suhasini R. Gopal, Aditi R. Deshmukh, Brian M.McDermott Jr., Brian M. McDermott Jr., Brian M. McDermott Jr., Brian M. McDermottJr., Kumar N. Alagramam, Kumar N. Alagramam, Kumar N. Alagramam, Ruben Stepanyan,Ruben Stepanyan 2017, 'Inhibition of Mitochondrial Division Attenuates Cisplatin-Induced Toxicity in theNeuromast Hair Cells', Frontiers in Cellular Neurosciencehttp://journal.frontiersin.org/article/10.3389/fncel.2017.00393/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)