The patient was successfully treated with a therapeutic dose of foscarnet.
Takashi Ishio, Tomoyuki Endo, Kohei Okada, Akio Shigematsu, Satoshi Hashino, TakanoriTeshima 2015, 'Human Herpesvirus-6 Pneumonitis around the Engraftment of Cord Blood Transplantationfollowing Foscarnet Prophylaxis in a Patient with Acute Leukemia', Case Reports in Hematologyhttp://dx.doi.org/10.1155/2015/949265. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The patient completed six weeks of combination antiviral therapy (ganciclovir and foscarnet).
Fernanda Leite de Souza Franceschi, Jaime Green, Zuzan Cayci, Evan Mariash, MustaphaEzzeddine, Veronika Bachanova, Celalettin Ustun 2014, 'Human Herpesvirus 6 is Associated with Status Epilepticus and Hyponatremia after UmbilicalCord Blood Transplantation', Canadian Journal of Infectious Diseases and Medical Microbiologyhttp://dx.doi.org/10.1155/2014/392720. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Foscarnet and cidofovir, however, are associated with nephrotoxicity.
El Helou G, Razonable RR 2019, 'Letermovir for the prevention of cytomegalovirus infection and disease in transplantrecipients: an evidence-based review', Infection and Drug Resistancehttps://www.dovepress.com/letermovir-for-the-prevention-of-cytomegalovirus-infection-and-disease-peer-reviewed-article-IDR. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The patient received foscarnet and imiquimod for two weeks with minimal improvement.
Marie R. Roger, Gregory M. Anstead 2017, 'Leflunomide in the Treatment of a Pseudotumoral Genital Herpes Simplex Virus Infectionin an HIV Patient', Case Reports in Infectious Diseaseshttp://dx.doi.org/10.1155/2017/1589356. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The patient was treated with pars plana vitrectomy, oral valganciclovir, and intravitreal foscarnet.
Matthew K. Adams, Christina Y. Weng 2019, 'Cytomegalovirus Retinitis Associated with Lenalidomide Use for Multiple Myeloma inan Immunocompetent Patient', Case Reports in Ophthalmological Medicinehttp://dx.doi.org/10.1155/2019/3516394. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Anti-viral agents such as ganciclovir or foscarnet are effective against cytomegalovirus infection.
Rao Narsing 1994, 'Acquired immunodeficiency syndrome and its ocular complications', Indian Journal of Ophthalmologyhttp://www.ijo.in/article.asp?issn=0301-4738;year=1994;volume=42;issue=2;spage=51;epage=63;aulast=Rao. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Treatment consisted of ganciclovir and foscarnet, followed by maintenance therapy with valganciclovir.
Pedro Palma, Andreia Costa, Raquel Duro, Nélia Neves, Cândida Abreu, António Sarmento 2018, 'Mononeuritis multiplex: an uncommon neurological manifestation of cytomegalovirusreactivation in an HIV-infected patient', BMC Infectious Diseaseshttp://link.springer.com/article/10.1186/s12879-018-3501-2. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Resistant cases are managed with foscarnet or cidofovir.
Nath Amiya, Thappa Devinder 2009, 'Newer trends in the management of genital herpes', Indian Journal of Dermatology, Venereology and Leprologyhttp://www.ijdvl.com/article.asp?issn=0378-6323;year=2009;volume=75;issue=6;spage=566;epage=574;aulast=Nath. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Herein, we present a review of foscarnet nephropathy cases in solid-organ transplanted patients.
Romain Vial, Christine Zandotti, Sophie Alain, Alexandre Decourt, Noémie Jourde-Chiche,Raj Purgus, Charleric Bornet, Laurent Daniel, Valérie Moal, Tristan Legris 2017, 'Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipientwith Multiresistant Cytomegalovirus Infection', Case Reports in Transplantationhttp://dx.doi.org/10.1155/2017/3624146. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Two weeks after stopping the infusion of foscarnet, the ulcers subsided without any additional treatment.
Jonas A. Adalsteinsson, Michael Pan, Shivani Kaushik, Jonathan Ungar 2018, 'Foscarnet-induced genital lesions: An overview with a case report', Dermatology Reportshttps://www.pagepress.org/journals/index.php/dr/article/view/7749. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)