an antibiotic drug used in the treatment of diarrhoea and enteritis
furazolidone in American English
(ˌfjurəˈzɑlɪˌdoun)
noun
Pharmacology
a nitrofuran, C8H7N3O5, that is used in the treatment of giardiasis, and bacterial gastroenteritis and dysentery
Word origin
[1950–55; prob. fur(anyl) + (ox)azolid(in)one, two of its chemical components]This word is first recorded in the period 1950–55. Other words that entered Englishat around the same time include: action painting, allograph, drip-dry, point-of-sale, wiretap
Examples of 'furazolidone' in a sentence
furazolidone
We revealed that all 63 strains were sensitive towards sitafloxacin, furazolidone, and rifabutin.
Muhammad Miftahussurur, Modesto Cruz, Dalla Doohan, Phawinee Subsomwong, José A. JiménezAbreu, Celso Hosking, Langgeng Agung Waskito, Yoshio Yamaoka 2019, 'Five alternative Helicobacter pylori antibiotics to counter high levofloxacin andmetronidazole resistance in the Dominican Republic', PLOS ONE10.1371/journal.pone.0213868. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
There was no observed resistance to amoxicillin, tetracycline or furazolidone.
Jaime Natan Eisig, Fernando Marcuz Silva, Ricardo Correa Barbuti, Tomás Navarro-Rodriguez,Joaquim Prado P Moraes-Filho, José Pedrazzoli Jr 2011, 'Helicobacter pylori antibiotic resistance in Brazil: clarithromycin is still a goodoption', Arquivos de Gastroenterologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032011000400008&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
About half of the farms used banned furazolidone and chloramphenicol.
O. O. Adebowale, O. K. Adeyemo, O. Awoyomi, R. Dada, O. Adebowale 2016, 'Antibiotic use and practices in commercial poultry laying hens in Ogun State Nigeria',Revue d'Elevage et de Médecine Vétérinaire des Pays Tropicauxhttp://revues.cirad.fr/index.php/REMVT/article/view/31170. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
No antibiotic resistance was found against furazolidone.
Tahereh Navidifar, Gilda Eslami, Mohsen Akhondi, Mahmood Baghbanian, Hossein FallahZadeh, Hengameh Zandi 2014, 'Antibacterial Resistance Patterns of Helicobacter pylori Clinical Isolates From GastricBiopsy of Patients in Yazd', International Journal of Enteric Pathogenshttp://enterpathog.abzums.ac.ir/PDF/ijep-2-17791.pdf. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The majority of isolates were resistant to ampicillin, furazolidone and nalidixic acid.
Raikamal Ghosh, Naresh C. Sharma, Kalpataru Halder, Rupak K Bhadra, Goutam Chowdhury,Gururaja Perumal Pazhani, Sumio Shinoda, Asish K. Mukhopadhyay, G. Balakrish Nair,Thandavarayan Ramamurthy 2016, 'Phenotypic and Genetic Heterogeneity in Vibrio cholerae O139 Isolated from CholeraCases in Delhi, India during 2001-2006', Frontiers in Microbiologyhttp://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01250/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Amoxicillin, gentamicin, and furazolidone are recommended as the first-line empiric regimen.
Ran Han, Hong Lu, Ming-Wan Jiang, Ke-Wen Tan, Zhong Peng, Jia-Li Hu, Dian-Chun Fang,Chun-Hui Lan, Xiao-Ling Wu 2016, 'Multicenter Study of Antibiotic Resistance Profile of H. pylori and Distribution ofCYP2C19 Gene Polymorphism in Rural Population of Chongqing, China', Gastroenterology Research and Practicehttp://dx.doi.org/10.1155/2016/8547686. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, some relevant safety concerns do exist in using furazolidone.
Angelo Zullo, Enzo Ierardi, Cesare Hassan, Vincenzo De Francesco 2012, 'Furazolidone-based therapies for Helicobacter pylori infection: A pooled-data analysis',The Saudi Journal of Gastroenterologyhttp://www.saudijgastro.com/article.asp?issn=1319-3767;year=2012;volume=18;issue=1;spage=11;epage=17;aulast=Zullo. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Some antibiotics, such as furazolidone, may be affordable agents to treat this infectionworldwide.
Eric Drouin 1999, 'Helicobacter pylori: Novel Therapies', Canadian Journal of Gastroenterologyhttp://dx.doi.org/10.1155/1999/485237. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Third-line therapy should be under culture guidance to select the most effective regimens (such as levofloxacin-based, rifabutin-based, or furazolidone-based therapies).
Tzung-Shiun Wu, Huang-Ming Hu, Fu-Chen Kuo, Chao-Hung Kuo 2014, 'Eradication of Helicobacter pylori infection', Kaohsiung Journal of Medical Scienceshttp://www.sciencedirect.com/science/article/pii/S1607551X13002969. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)