Some malignant cells are unable to synthesise their own asparagine and this has beenexploited in the development of therapeutic regimes for the treatment of some typesof leukaemia. Asparaginase is an enzyme which breaks down asparagine
asparaginase in American English
(əˈspærədʒəˌneis, -ˌneiz)
noun
Biochemistry & Pharmacology
an enzyme that catalyzes the conversion of asparagine to aspartic acid and ammonia, used in the treatment of acute lymphocytic leukemia
Word origin
[1960–65; asparagine + -ase]This word is first recorded in the period 1960–65. Other words that entered Englishat around the same time include: bicycle kick, deinstitutionalize, disco, parvovirus, zip code-ase is a suffix used in the names of enzymes. Other words that use the affix -ase include: invertase, lipase, peroxidase, phosphorylase, transferase
Examples of 'asparaginase' in a sentence
asparaginase
This can be achieved by the treatment of beans with the enzyme asparaginase.
Ana Carolina Vieira Porto, Otniel Freitas-Silva, Erika Fraga de Souza, Leda MariaFortes Gottschalk 2019, 'Effect of Asparaginase Enzyme in the Reduction of Asparagine in Green Coffee', Beverageshttps://www.mdpi.com/2306-5710/5/2/32. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Refolded asparaginase was purified in two steps using ion-exchange and gel filtration chromatographic techniques.
Arun K Upadhyay, Anupam eSingh, K J Mukherjee, Amulya Kumar Panda 2014, 'Refolding and purification of recombinant L-asparaginase from inclusion bodies ofE. coli in to active tetrameric protein', Frontiers in Microbiologyhttp://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00486/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The soaking and frying conditions were optimized using free and chitosan-immobilized asparaginase.
Baskar Gurunathan, Aiswarya Ravi 2018, 'Acrylamide Mitigation in Fried Kochchi Kesel Chips Using Free and Immobilized FungalAsparaginase', Food Technology and Biotechnologyhttp://hrcak.srce.hr/file/290725. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Enzymatic activity of asparaginase was measured via a modified asparagine assay.
Jackie M. Wypij, Holly C. Pondenis 2013, 'E. coli-Derived L-Asparaginase Retains Enzymatic and Cytotoxic Activity In Vitro forCanine and Feline Lymphoma after Cold Storage', Veterinary Medicine Internationalhttp://dx.doi.org/10.1155/2013/786162. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
L-asparaginase from bacteria has been used in treatment of acute lymphoblastic leukemia.
Saleh A. Mohamed, Mohamed F. Elshal, Taha A. Kumosani, Alia M. Aldahlawi 2015, 'Purification and Characterization of Asparaginase from Phaseolus vulgaris Seeds',Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1155/2015/309214. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The recovery of bioactive asparaginase from inclusion bodies was around 50 %.
Arun K Upadhyay, Anupam eSingh, K J Mukherjee, Amulya Kumar Panda 2014, 'Refolding and purification of recombinant L-asparaginase from inclusion bodies ofE. coli in to active tetrameric protein', Frontiers in Microbiologyhttp://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00486/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We conclude that asparaginase can potentiate the osteonecrotic effect of glucocorticoids.
Chengcheng Liu, Laura J Janke, Jitesh D Kawedia, Laura B Ramsey, Xiangjun Cai, LeonardA Mattano, Kelli L Boyd, Amy J Funk, Mary V Relling 2016, 'Asparaginase Potentiates Glucocorticoid-Induced Osteonecrosis in a Mouse Model.',PLoS ONEhttp://europepmc.org/articles/PMC4788417?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Nine similar published cases of asparaginase-induced hypertriglyceridemia and its complications are also discussed.
Ashley Hinson, Dorothee Newbern, Corinne M. Linardic 2014, 'Asparaginase-Induced Hypertriglyceridemia Presenting as Pseudohyponatremia duringLeukemia Treatment', Case Reports in Pediatricshttp://dx.doi.org/10.1155/2014/635740. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Moreover, carbon:nitrogen ratio (1:0.025) strongly affected the response of asparaginase activity.
Francieli Bortoluzzi Menegat, Cristiani Baldo, Maria Antonia Pedrine Colabone Celligoi,João Batista Buzato 2016, 'Optimization of asparaginase production from Zymomonas mobilis by continuousfermentation', Acta Scientiarum : Biological Scienceshttp://www.periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/31057. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The purified asparaginase had very low activity toward a number of asparagine and glutamine analogues.
Saleh A. Mohamed, Mohamed F. Elshal, Taha A. Kumosani, Alia M. Aldahlawi 2015, 'Purification and Characterization of Asparaginase from Phaseolus vulgaris Seeds',Evidence-Based Complementary and Alternative Medicinehttp://dx.doi.org/10.1155/2015/309214. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)