a diuretic that increases water loss from the kidneys and is much used to treat oedema in heart and kidney failure
Word origin
C20: from spiro-2 + linking syllable -no- + lactone
Examples of 'spironolactone' in a sentence
spironolactone
No patients experienced electrolyte imbalance after spironolactone treatment.
Jin Young Kim, Ju Byung Chae, Jisoo Kim, Dong Yoon Kim 2018, 'Mineralocorticoid Receptor Antagonist Treatment for Steroid-Induced Central SerousChorioretinopathy Patients with Continuous Systemic Steroid Treatment', Journal of Ophthalmologyhttp://dx.doi.org/10.1155/2018/4258763. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Serum potassium was compared prior to initiation of spironolactone and two months afterwards.
Amit Langote, Swapnil Hiremath, Marcel Ruzicka, Brendan B McCormick 2017, 'Spironolactone is effective in treating hypokalemia among peritoneal dialysis patients.',PLoS ONEhttp://europepmc.org/articles/PMC5681284?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Amongst these patients, 28 patients were on spironolactone and 36 were not takingspironolactone.
Abdul Wase, Naga Garikipati, Omar Mufti, Zulfiqar Mirza, Aparna Innaparthy, AnwarulKabir, Mohammed B. Quraishi, Ronald Markert 2012, 'Effect of spironolactone on ventricular arrhythmias in patients with left ventricularsystolic dysfunction and implantable cardioverter defibrillators', Indian Heart Journalhttp://www.sciencedirect.com/science/article/pii/S0019483212600443. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
He responded well to spironolactone and indomethacin.
Chamara Dalugama, Manoji Pathirage, S. A. M. Kularatne 2018, 'Bartter syndrome-like phenotype in a patient with diabetes: a case report', Journal of Medical Case Reportshttp://link.springer.com/article/10.1186/s13256-018-1752-6. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Blood pressure increased similarly among strains after clipping and was unaffected by spironolactone.
Larisa H. Cavallari, Lucy A. Fashingbauer, Joseph R. Camp, Stephen T. King, DavidL. Geenen 2008, 'Hypertension-induced renal fibrosis and spironolactone response vary by rat strainand mineralocorticoid receptor gene expression', Journal of the Renin-Angiotensin-Aldosterone Systemhttps://doi.org/10.1177/1470320308096367. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The addition of spironolactone decreased the transversal myocyte hypertrophy by 14.6%.
Maria Luiza Mendonça Pereira Fernandes, Eloísa Amália Vieira Ferro, Marcelo EmilioBeletti, Elmiro Santos Resende 2007, 'Efeitos da espironolactona sobre as alterações miocárdicas induzidas pelo hormôniotireoideano em ratos Spironolactone effects on myocardium changes induced by thyroidhormone in rats', Arquivos Brasileiros de Cardiologiahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0066-782X2007001800008. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Spironolactone was administered and hepatic injury, cytokine production, and oxidative stress were assessed.
Julio César Jiménez Pérez, Araní Casillas Ramírez, Liliana Torres González, LindaElsa Muñoz Espinosa, Marlene Marisol Perales Quintana, Gabriela Alarcón Galván, HomeroZapata Chavira, Francisco Javier Guzmán de la Garza, Carlos Rodrigo Cámara Lemarroy,Nancy Esthela Fernández Garza, Edelmiro Pérez Rodríguez, Paula Cordero Pérez 2016, 'Spironolactone Effect in Hepatic Ischemia/Reperfusion Injury in Wistar Rats', Oxidative Medicine and Cellular Longevityhttp://dx.doi.org/10.1155/2016/3196431. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Spironolactone was also shown to be an effective alternative treatment with good tolerability.
M.K. Trivedi, BS, BA, K. Shinkai, MD, PhD, J.E. Murase, MD 2017, 'A Review of hormone-based therapies to treat adult acne vulgaris in women', International Journal of Women's Dermatologyhttp://www.sciencedirect.com/science/article/pii/S2352647517300291. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
However, spironolactone did not influence any of these variables.
Marcos F Minicucci, Priscila P dos Santos, Bruna P M Rafacho, Andrea F Gonçalves,Renata A C Silva, Fernanda Chiuso-Minicucci, Paula S Azevedo, Bertha F Polegato, KatashiOkoshi, Elenize J Pereira, Sergio A R Paiva, Leonardo A M Zornoff 2013, 'Mechanisms involved in the beneficial effects of spironolactone after myocardial infarction.',PLoS ONEhttp://europepmc.org/articles/PMC3786966?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)