Yet, it was lower in the groups treated with the combination trypanocide/antibiotic (p<0.01).
Vincent Delespaux, Hervé Sèna Vitouley, Tanguy Marcotty, Niko Speybroeck, Dirk Berkvens,Krisna Roy, Stanny Geerts, Peter Van den Bossche 2010, 'Chemosensitization of Trypanosoma congolense strains resistant to isometamidium chlorideby tetracyclines and enrofloxacin.', PLoS Neglected Tropical Diseaseshttp://europepmc.org/articles/PMC2946901?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Twenty nine patients received trypanocide treatment and 37 remained untreated.
Diana Fabbro, Elsa Velazquez, Maria Laura Bizai, Susana Denner, Verónica Olivera,Enrique Arias, Carlos Pravia, Andrés M. Ruiz 2013, 'Evaluation of the ELISA-F29 test as an early marker of therapeutic efficacy in adultswith chronic Chagas disease', Revista do Instituto de Medicina Tropical de São Paulohttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652013000300167&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Here, we investigated the trypanocide activity of temporizin and temporizin-1.
André L A Souza, Robson X Faria, Kátia S Calabrese, Daiane J Hardoim, Noemi Taniwaki,Luiz A Alves, Salvatore G De Simone 2016, 'Temporizin and Temporizin-1 Peptides as Novel Candidates for Eliminating Trypanosomacruzi.', PLoS ONEhttp://europepmc.org/articles/PMC4934777?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We conclude that a potent and highly selective new trypanocide may be present in the fraction.
Weam Siheri, Godwin U. Ebiloma, John O. Igoli, Alexander I. Gray, Marco Biddau, PilaslakAkrachalanont, Samya Alenezi, Mohammad A. Alwashih, RuAngelie Edrada-Ebel, Sylke Muller,Catherine E. Lawrence, James Fearnley, David G. Watson, Harry P. De Koning 2019, 'Isolation of a Novel Flavanonol and an Alkylresorcinol with Highly Potent Anti-TrypanosomalActivity from Libyan propolis', Moleculeshttp://www.mdpi.com/1420-3049/24/6/1041. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)