an organelle within a melanocyte that contains melanin
melanosome in American English
(ˈmɛlənoʊˌsoʊm; məˈlænəsoʊm)
noun
an organelle of a cell containing densely packed melanin pigments along rows of tiny fibers
melanosome in American English
(məˈlænəˌsoum, ˈmelənə-)
noun
Biology
an organelle in melanocytes that synthesizes and stores melanin
Word origin
[1935–40; melano- + -some3]This word is first recorded in the period 1935–40. Other words that entered Englishat around the same time include: Rhodesian ridgeback, complementation, prime mover, roadblock, unit trust-some is a combining form meaning “body,” used in the formation of compound words. Otherwords that use the affix -some include: endosome, nucleosome, phagosome, schistosome, trypanosome
Examples of 'melanosome' in a sentence
melanosome
Melanosome research would benefit from a method to isolate pure and characterized melanosomes.
Laura Pelkonen, Mika Reinisalo, Emmanuelle Morin-Picardat, Heidi Kidron, Arto Urtti 2016, 'Isolation of Intact and Functional Melanosomes from the Retinal Pigment Epithelium',PLOS ONE10.1371/journal.pone.0160352. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Interestingly, melanosome trafficking components were also overexpressed in the attached and in vivo basal keratinocytes.
Tomohiro Banno, Miroslav Blumenberg 2014, 'Keratinocyte detachment-differentiation connection revisited, or anoikis-pityriasinexus redux.', PLoS ONEhttp://europepmc.org/articles/PMC4069014?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our results demonstrate that multiple force-producing units cooperatively transport a single melanosome.
Shin Hasegawa, Takashi Sagawa, Kazuho Ikeda, Yasushi Okada, Kumiko Hayashi 2019, 'Investigation of multiple-dynein transport of melanosomes by non-invasive force measurementusing fluctuation unit χ', Scientific Reportshttp://link.springer.com/article/10.1038/s41598-019-41458-w. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Similar observations were obtained from the naked melanosome model in vitro.
Fang Miao, Ying Shi, Zhi-Feng Fan, Shan Jiang, Shi-Zheng Xu, Tie-Chi Lei 2016, 'Deoxyarbutin Possesses a Potent Skin-Lightening Capacity with No Discernible Cytotoxicityagainst Melanosomes', PLOS ONE10.1371/journal.pone.0165338. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It also affects expression of other factors regulating melanosome maturation, biogenesis and transport.
Michał Otręba, Jakub Rok, Ewa Buszman, Dorota Wrześniok 2012, 'Regulation of melanogenesis: the role of cAMP and MITF', Postępy Higieny i Medycyny Doświadczalnejhttp://journals.indexcopernicus.com/fulltxt.php?ICID=979388. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Numerous anti-melanogenic agents that target tyrosinase activity/stability, melanosome maturation/transfer, or melanogenesis-related signaling pathways have been developed.
Bum-Ho Bin, Sung Tae Kim, Jinhyuk Bhin, Tae Ryong Lee, Eun-Gyung Cho 2016, 'The Development of Sugar-Based Anti-Melanogenic Agents', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/17/4/583. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Identification of keratinocytes and melanocytes was made through immunocytochemical staining for cytokeratin and melanosome antigens, respectively.
Mohsen Khosravi Maharlooei, Ali Akbar Mohammadi, Ali Farsi, Iman Ahrari, Armin Attar,Ahmad Monabati 2011, 'A comparison between different existing methods used to separate epidermal cells fromskin biopsies for autologous transplantation', Indian Journal of Dermatologyhttp://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=6;spage=666;epage=669;aulast=Maharlooei. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Knowledge of their ultrastructure will be crucial to gaining insight into the mechanisms that ultimately lead to melanosome-related diseases.
Thomas Gorniak, Tamas Haraszti, Vasyl M Garamus, Andreas R Buck, Tobias Senkbeil,Marius Priebe, Adam Hedberg-Buenz, Demelza Koehn, Tim Salditt, Michael Grunze, MichaelG Anderson, Axel Rosenhahn 2014, 'Nano-scale morphology of melanosomes revealed by small-angle X-ray scattering.', PLoS ONEhttp://europepmc.org/articles/PMC3951238?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Immunocytochemical staining showed that in all methods, some cells are stained positively for cytokeratin antibody and some for melanosome antibody.
Mohsen Khosravi Maharlooei, Ali Akbar Mohammadi, Ali Farsi, Iman Ahrari, Armin Attar,Ahmad Monabati 2011, 'A comparison between different existing methods used to separate epidermal cells fromskin biopsies for autologous transplantation', Indian Journal of Dermatologyhttp://www.e-ijd.org/article.asp?issn=0019-5154;year=2011;volume=56;issue=6;spage=666;epage=669;aulast=Maharlooei. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)