any of a group of glycoproteins that form part of the structure of lipoproteins, some of which have been associated with Alzheimer's disease
apolipoprotein in American English
(ˌæpəˌlɪpəˈproutin, -tiɪn, -ˌlaipə-)
noun
Biochemistry
the lipid-free protein portion of a lipoprotein
Word origin
[apo- + lipoprotein]apo- is a prefix occurring originally in loanwords from Greek, where it was joined toverbs, deverbal forms, and other parts of speech. Among its functions in Greek, apo- has the spatial sense “away, off, apart” (apogee; apocope; apostasy; apostrophe); it occurs with deverbals that denote a response or defense (apodosis; apology) and is found on verbs having perfective force relative to a corresponding simpleverb (apoplexy; aposiopesis). In modern scientific coinages in English and other languages, apo- marks things that are detached, separate, or derivative (apocarpous; apoenzyme)
Examples of 'apolipoprotein' in a sentence
apolipoprotein
Intriguingly, apolipoprotein ε4 carriers had significantly higher string vessel counts relative to non-ε4 carriers.
Jesse M. Hunter, Jason Kwan, Michael Malek-Ahmadi, Chera L. Maarouf, Tyler A. Kokjohn,Christine Belden, Marwan N. Sabbagh, Thomas G. Beach, Alex E. Roher 2012, 'Morphological and Pathological Evolution of the Brain Microcirculation in Aging andAlzheimer's Disease', PLoS ONE10.1371/journal.pone.0036893. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In the future, an antisense oligonucleotide against apolipoprotein(a) may offer an alternative therapeutic approach.
Ulrich Julius 2018, 'Current Role of Lipoprotein Apheresis in the Treatment of High-Risk Patients', Journal of Cardiovascular Development and Diseasehttp://www.mdpi.com/2308-3425/5/2/27. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Decreased liver proteins included phosphoglycerate kinase, apolipoprotein and perilipin.
Sandra Murphy, Margit Zweyer, Michael Henry, Paula Meleady, Rustam R. Mundegar, DieterSwandulla, Kay Ohlendieck 2018, 'Proteomic profiling of liver tissue from the mdx-4cv mouse model of Duchenne musculardystrophy', Clinical Proteomicshttp://link.springer.com/article/10.1186/s12014-018-9212-2. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Apolipoprotein and fibronectin concentrations were determined with nephelometric methods.
Ayşe Binnur Erbağcı, Mehmet Tarakçıoğlu, Ahmet Erbağcı, Mehmet Gözübüyük, Necat Yılmaz,Rukiye Deveci, Ramazan Kocabaş 2002, 'Triglycerides Predict Plasma Fibronectin in Children with Type I Diabetes MellitusRather than Diabetes', Acta Medicahttps://actamedica.lfhk.cuni.cz/45/1/0033/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Serum lipid and apolipoprotein levels were measured.
Dezhai Yang, Weixiong Lin, Yong Wang, Guangqin Chen, Ruixing Yin, Shangling Pan 2007, 'Effect of the 3'APOB-VNTR polymorphism on the lipid profiles in the Guangxi Hei YiZhuang and Han populations', BMC Medical Geneticshttp://www.biomedcentral.com/1471-2350/8/45. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Infiltration of macrophages was seen in all valves and there were no differences regarding deposition of apolipoprotein.
Lars Wallby, Thora Steffensen, Lena Jonasson, Mats Broqvist 2013, 'Inflammatory Characteristics of Stenotic Aortic Valves: A Comparison between Rheumaticand Nonrheumatic Aortic Stenosis', Cardiology Research and Practicehttp://dx.doi.org/10.1155/2013/895215. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our findings further assign an intracellular role to a member of the apolipoprotein family in mammals.
Tobias A Weber, Sebastian Koob, Heinrich Heide, Ilka Wittig, Brian Head, Alexandervan der Bliek, Ulrich Brandt, Michel Mittelbronn, Andreas S Reichert 2013, 'APOOL is a cardiolipin-binding constituent of the Mitofilin/MINOS protein complexdetermining cristae morphology in mammalian mitochondria.', PLoS ONEhttp://europepmc.org/articles/PMC3660581?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Our results describe a novel regulatory mechanism of transcription of apolipoprotein genes by quercetin in the intestinal enterocytes.
Makoto Shimizu, Juan Li, Jun Inoue, Ryuichiro Sato 2015, 'Quercetin represses apolipoprotein B expression by inhibiting the transcriptionalactivity of C/EBPβ.', PLoS ONEhttp://europepmc.org/articles/PMC4398426?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)