| Acronym | Definition |
|---|
| HLS➣Hills |
| HLS➣Harvard Law School |
| HLS➣High-Level Synthesis |
| HLS➣Homeland Security |
| HLS➣Huntingdon Life Sciences (research laboratory, Cambridgeshire, England) |
| HLS➣High Level Structure (International Organization for Standardization) |
| HLS➣Higher Level Stewardship (UK; agriculture) |
| HLS➣Healthcare and Life Sciences |
| HLS➣Helicopter Landing Site |
| HLS➣Hue Lightning Saturation |
| HLS➣High Line Super |
| HLS➣Home Location Server |
| HLS➣High Level Service |
| HLS➣Higher Level Skills |
| HLS➣Helicopter Landing System |
| HLS➣Hue, Lightness, Saturation (color model, aka HVS) |
| HLS➣Hard Luck Story |
| HLS➣Hispanic Linguistics Symposium (various locations) |
| HLS➣Hawkes Learning Systems (software) |
| HLS➣Hurricane Local Statement (US FEMA) |
| HLS➣Heat, Light and Sound (various organizations) |
| HLS➣Health Level Seven (healthcare) |
| HLS➣Handheld Laser Scanner |
| HLS➣Human Lineage Specific (genetics) |
| HLS➣High Level Sports |
| HLS➣Hot Lime Softener (water softener) |
| HLS➣Healthy Living Strategy (Canada) |
| HLS➣Heavy Louisiana Sweet (crude oil) |
| HLS➣Hawken Locksmith Services (DeKalb, IL) |
| HLS➣Healthy Living Seminar |
| HLS➣Hook Loop Strap (product feature) |
| HLS➣Home Library Service |
| HLS➣Halt Line State (Cisco) |
| HLS➣Hydraulic Locomotive Shed (Sri Lanka) |
| HLS➣Home Loan Servicing |
| HLS➣Hot Lava Software |
| HLS➣Homeland Support |
| HLS➣Hyperbaric Lighting Set |
| HLS➣Huge Lawn Software (Denmark) |
| HLS➣Hybrid Transmission with Layered Source |
| HLS➣Horizontal Layered Schedule |
| HLS➣Hysterical Laughter Syndrome |
| HLS➣HTTP (Hypertext Transfer Protocol) Live Streaming (Apple) |