myxedema

myx·e·de·ma

or myx·oe·de·ma M0515900 (mĭk′sĭ-dē′mə)n. A disease caused by decreased activity of the thyroid gland in adults and characterized by dry skin, swellings around the lips and nose, mental deterioration, and a subnormal basal metabolic rate.

myx′e·dem′a·tous (-dĕm′ə-təs, -dē′mə-), myx′e·dem′ic (-dĕm′ĭk) adj.

myx•e•de•ma

(ˌmɪk sɪˈdi mə)

n. a condition characterized by thickening of the skin, blunting of the senses and intellect, and labored speech, associated with hypothyroidism. [1875–80]

myxedema, myxoedema

a disease resulting from the decreased function of the thyroid, characterized by a slowing down of mental and physical activity and thickening and drying of the skin. — myxedematous, myxedoematous, adj.See also: Disease and Illness

myxedema

Accumulation of water in skin resulting from thyroid hormone deficiency in adults.

Thesaurus

Noun

myxedema - hypothyroidism marked by dry skin and swellings around lips and nose as well as mental deteriorationmyxoedemahypothyroidism - an underactive thyroid gland; a glandular disorder resulting from insufficient production of thyroid hormones

Translations

myxedema

(mĭksədē`mə), condition associated with severe hypothyroidism and lack of thyroid hormone in the adult. In the child it is known as cretinismcretinism
, condition produced in infants and children due to lack of thyroid hormone. It usually results from a congenital defect (e.g., absence of the thyroid, presence of only a rudimentary gland, inability of the gland to produce thyroxine).
..... Click the link for more information. . Symptoms include a dry swelling of the skin, slowed speech and mental awareness, deepened voice, intolerance to cold, fatigue and weakness, and nonspecific degeneration of the heart. Most cases result from atrophy of the thyroid from unknown causes, although surgical removal or irradiation of the gland also precipitates the disorder. Myxedema is treated by administering synthetic preparations of thyroxine (thryoid hormone), liothyronine (triiiodothyronine), a combination of the two synthetic hormones, and desicated animal thyroid.

Myxedema

a disease caused by thyroid insufficiency (hypothyroidism) or complete thyroid failure. Thyroid and hypothalamic-pituitary myxedema are differentiated.

Thyroid myxedema may be congenital—resulting from abnormal intrauterine development, toxicoses of pregnancy, or intrauterine infection (syphilis, viral infections)—or acquired—resulting from injury or acute or chronic inflammation of the thyroid gland. This form of myxedema may also result from an autoimmune reaction against the body’s own thyroglobulin. Hypothalamic-pituitary myxedema is due to functional and organic changes that interfere with the production of the TSH-releasing factor of the hypothalamus or the thyrotropic hormone of the pituitary.

The main symptoms of myxedema are mucous edema of the skin and subcutaneous tissue, dry skin, sluggishness, drowsiness, poor memory, physical and mental lassitude, lowered basal metabolism, constant sensitivity to cold, lowered blood pressure, slow pulse, and intestinal sluggishness causing constipation. Myxedematous children suffer from dwarfism, slow bone growth, late eruption of the teeth, brittleness of nails, and mental disorders. Treatment includes the regular administration of thyroid preparations (thyroidin) and triiodothyronine.

REFERENCES

Baranov, V. G. Bolezni endokrinnoi sistemy i obmena veshchestv. [Leningrad] 1955.
Tareev, E. M. Vnutrennie bolezni, 3rd ed. Moscow, 1957.
Mnogotomnoe rukovodstvo po patologicheskoi fiziologii, vol. 4. Moscow [1966]. Pages 228–29.

L. M. GOL’BER

myxedema

[‚miks·ə′dē·mə] (medicine) A condition caused by hypothyroidism characterized by a subnormal basal metabolic rate, dry coarse hair, loss of hair, mental dullness, anemia, and slowed reflexes.

myxoedema

(US), myxedema a disease resulting from underactivity of the thyroid gland characterized by puffy eyes, face, and hands and mental sluggishness

myxedema

enUK

myxedema

[mik″sĕ-de´mah] a condition resulting from advanced hypothyroidism" >hypothyroidism, or deficiency of thyroxine" >thyroxine; it is the adult form of the disease whose congenital form is known as cretinism. adj., adj myxedem´atous.
Myxedema may be caused by lack of iodine in the diet; by atrophy, surgical removal, or a disorder of the thyroid gland; by destruction of the gland by radioactive iodine; or by deficient excretion of thyrotropin by the pituitary gland. It is marked primarily by a growing puffiness or “sogginess” of the skin, edema" >nonpitting edema, abnormal deposits of mucin in the skin, and distinctive facial changes such as swollen lips and a thickened nose.
Because thyroxine plays such an important role in the body's metabolism, lack of this hormone seriously upsets the balance of body processes. Among the symptoms associated with myxedema are excessive fatigue and drowsiness, headaches, weight gain, dryness of the skin, sensitivity to cold, and increasing thinness and brittleness of the nails. In women, menstrual bleeding may become irregular. Medical tests reveal slow tendon reflexes, low blood iodine, below-normal metabolism, and abnormal uptake of radioactive iodine by the thyroid.
The body's defenses against infection also are weakened. If the patient has heart disease, it may worsen. Upset of the functions of the adrenal glands may become critical. In time, if myxedema is not brought under control, progressive mental deterioration may result in a psychosis marked by paranoid delusions.
Myxedema is treated by administration of thyroid extract or similar synthetic preparations. If treatment is begun soon after the symptoms appear, recovery may be complete. Delayed or interrupted treatment may mean permanent deterioration. In most instances, treatment with thyroid hormones or synthetics must be continued throughout the patient's lifetime.pretibial myxedema localized skin lesions associated with preceding hyperthyroidism, found most often on the front of the legs. It is almost always associated with graves' disease, occurring in 0.5 to 5 per cent of patients. Called also thyroid dermopathy.

myx·e·de·ma

(miks'e-dē'mă), [MIM*255900] Hypothyroidism characterized by a relatively hard edema of subcutaneous tissue, with increased content of mucins (proteoglycans) in the interstitial fluid; characterized by somnolence, slow mentation, dryness and loss of hair, increased fluid in body cavities such as the pericardial sac, subnormal temperature, hoarseness, muscle weakness, and slow return of a muscle to the neutral position after a tendon jerk; usually caused by removal or loss of functioning thyroid tissue. [myx- + G. oidēma, swelling]

myxedema

myxoedema

(mĭk′sĭ-dē′mə)n. A disease caused by decreased activity of the thyroid gland in adults and characterized by dry skin, swellings around the lips and nose, mental deterioration, and a subnormal basal metabolic rate.

myx′e·dem′a·tous (-dĕm′ə-təs, -dē′mə-), myx′e·dem′ic (-dĕm′ĭk) adj.

myxedema

Endocrinology Severe hypothyroidism characterized by yellowish discoloration, nonpitting edema, especially facial, accompanied by periorbital puffiness, puffy lips, and tongue, hoarse voice and sluggish movement; myxedema elicits several reactions a sui generis Myxedema Myxedema coma A complication of severe hypothyroidism, characterized by a loss of consciousness, which may be iatrogenic–sedatives in hypothyroidism are very slowly metabolized, may be due to infections or cold exposure; or rarely, occurring spontaneously Mortality 20-50% Myxedema madness A condition most common in the elderly, characterized by impaired hearing and memory, acalculia, somnolence, psychologic withdrawal, and paranoia Myxedema megacolon Pseudo-obstruction due to ↓ GI motility Myxedema wit Confabulation or use of humorous non-sequiturs by a hypothyroid Pt in order to draw the interviewer's attention away from the Pt's impaired memory

myx·e·de·ma

(miks'ĕ-dē'mă) Nonpitting waxy edema of the skin, often most pronounced in the face and shins (pretibial myxedema), owing to subcutaneous deposition of mucoid material in hypothyroidism.
Synonym(s): myxoedema. [myx- + G. oidēma, swelling]

Myxedema

A condition that can result from a thyroid gland that produces too little of its hormone. In addition to a decreased metabolic rate, symptoms may include anemia, slow speech, an enlarged tongue, puffiness of the face and hands, loss of hair, coarse and thickened skin, and sensitivity to cold.Mentioned in: Hypothyroidism, Thyroid Function Tests

myx·e·de·ma

(miks'ĕ-dē'mă) [MIM*255900] Hypothyroidism with a relatively hard edema of subcutaneous tissue, with increased content of mucins (proteoglycans) in the interstitial fluid; characterized by somnolence, slow mentation, dryness and loss of hair, increased fluid in body cavities such as the pericardial sac, subnormal temperature, hoarseness, muscle weakness, and slow return of a muscle to the neutral position after a tendon jerk.
Synonym(s): myxoedema. [myx- + G. oidēma, swelling]

myxedema

myx·e·de·ma

myx•e•de•ma

myxedema, myxoedema

myxedema

myxedema

myxedema

Myxedema

REFERENCES

myxedema

myxoedema

myxedema

myxedema

myx·e·de·ma

myxedema

myxoedema

myxedema

myx·e·de·ma

Myxedema

myx·e·de·ma

myxedema

Synonyms for myxedema

noun hypothyroidism marked by dry skin and swellings around lips and nose as well as mental deterioration

Synonyms

Related Words