ADME parameters

The critical pharmacokinetic hurdles —absorption, distribution, metabolism, elimination—that a drug must address before being approved by the FDA for clinical use. Of the four, metabolism (biotransformation) is regarded as the most important and complex, as it affects oral bioavailability, systemic exposure, inter-subject variability and drug-drug interactions.

ADME parameters

Drug development The critical–absorption, distribution, metabolism, elimination pharmacokinetic–'hoops' that a drug must jump through before FDA approval for clinical use. See Pharmacokinetics.

单词	adme parameters
释义	ADME parameters ADME parameters The critical pharmacokinetic hurdles —absorption, distribution, metabolism, elimination—that a drug must address before being approved by the FDA for clinical use. Of the four, metabolism (biotransformation) is regarded as the most important and complex, as it affects oral bioavailability, systemic exposure, inter-subject variability and drug-drug interactions. ADME parameters Drug development The critical–absorption, distribution, metabolism, elimination pharmacokinetic–'hoops' that a drug must jump through before FDA approval for clinical use. See Pharmacokinetics.
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