laetrile
enUKla·e·trile
L0015800 (lā′ĭ-trĭl′, -trəl)laetrile
(ˈleɪəˌtraɪl)la•e•trile
(ˈleɪ ɪ trɪl)n.
| Noun | 1. | laetrile - a substance derived from amygdalin; publicized as an antineoplastic drug although there is no supporting evidence |
| 单词 | laetrile | |||
| 释义 | laetrileenUKla·e·trileL0015800 (lā′ĭ-trĭl′, -trəl)laetrile(ˈleɪəˌtraɪl)la•e•trile(ˈleɪ ɪ trɪl)n.
laetrileenUKlaetrile(lā`ətrĭl'), name given to the chemical amygdalin, a substance derived from an extract of the kernels of many fruits, notably apricots, bitter almonds, and peaches. The idea that laetrile might selectively destroy cancer cells was developed by Dr. Ernst T. Krebs, Sr., a German immigrant to the United States, in the 1920s and was later refined by his son Ernst T. Krebs, Jr., who used the name "vitamin B17" for amygdalin and the derivatives of amygdalin that he developed. The Krebses had hypothesized that an enzyme that was more abundant in tumor cells than normal cells acted on laetrile to produce cytotoxic cyanide. (Cyanide is naturally produced in the intestines when laetrile is acted upon by intestinal bacteria.) This hypothesis and several refinements of it were proved to be untrue, as was the younger Krebs's later classification of the substance as a vitamin.The subject of controversy for many years, laetrile was subjected to much scientific scrutiny in the 1970s. Investigations showed that anecdotal reports of improvement with laetrile were insufficient proof of effectiveness. Clinical trials showed no effectiveness in shrinking tumors, prolonging survival, or improving the quality of the patient's life. Toxicity from cyanide poisoning in some patients, coupled with the drug's ineffectiveness, led the Food and Drug Administration to label laetrile a fraud. Interstate shipment and shipment from other countries are illegal, but it is still legal in some states and in Mexico. laetrileenUKlaetrile[la´ĕ-tril]la·e·trile(lā'ĕ-tril),laetrile(lā′ĭ-trĭl′, -trəl)laetrileAmygdalin Quackery A cyanide-rich bitter almond, apricot or peach pit extract, claimed to be effective in treating cancer. See Manner cocktail, Tijuana, Unproven methods of cancer management.la·e·trile(lā'ĕ-tril)laetrileA substance, amygdalin, derived from the seeds of bitter almonds, apricots and other fruit, that has been claimed to be effective in treating cancer. It is said to yield a cyanide-containing compound, mandelonitrile, under the action of enzymes said to be more plentiful in cancers than in normal tissue. There is no medically acceptable evidence that laetrile has any value in the treatment of cancer.laetrileenUK
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