MMP20
MMP20
A gene on chromosome 11q22.3 that encodes matrix metalloproteinase 20, which degrades amelogenin, the major protein of the enamel matrix, and two macromolecules of the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein. MMP20 may play a central role in tooth enamel formation. It is also the retired HUGO symbol for what is now designated MMP25, see there.Molecular pathology
Defects in MMP20 cause amelogenesis imperfecta type 2A2.