bioavailability

bi·o·a·vail·a·bil·i·ty

B0260400 (bī′ō-ə-vā′lə-bĭl′ĭ-tē)n. The degree to which or rate at which a drug or other substance is absorbed or becomes available at the site of physiological activity after administration.

bi′o·a·vail′a·ble (-lə-bəl) adj.

bioavailability

(ˌbaɪəʊəˌveɪləˈbɪlɪtɪ) n (Medicine) the extent to which a drug or other substance is taken up by a specific tissue or organ after administration; the proportion of the dose of a drug that reaches the systemic circulation intact after administration by a route other than intravenous. Also called: systemic availability ˌbioaˈvailable adj

bi•o•a•vail•a•bil•i•ty

(ˌbaɪ oʊ əˌveɪ ləˈbɪl ɪ ti)

n. the extent to which a substance can be used by the body. [1965–70] bi`o•a•vail′a•ble, adj.

bioavailability

[bi″o-ah-vāl″ah-bil´ĭ-te] the degree to which a drug or other substance becomes available to the target tissue after administration.

bi·o·a·vail·a·bil·i·ty

(bī'ō-ă-vāl'ă-bil'i-tē), The physiologic availability of a given amount of a drug, as distinct from its chemical potency; proportion of the administered dose that is absorbed into the bloodstream.

bioavailability

(bī′ō-ə-vā′lə-bĭl′ĭ-tē)n. The degree to which or rate at which a drug or other substance is absorbed or becomes available at the site of physiological activity after administration.

bi′o·a·vail′a·ble (-lə-bəl) adj.

bioavailability

The rate and extent to which a drug is available to serve as a substrate, bind to a specific molecule or participate in biochemical reactions in a target tissue after administration. For oral agents, bioavailability reflects the rate and extent of GI tract absorption.
Bioavailability depends on the pI (isoelectric point), the pH of a solution in which the solute does not migrate (ionic form), presence of side chains or the conformation of the epitope. Bioavailability is affected by the route of administration, rate of metabolism, lipid solubility and binding proteins. It is usually < 100% due to degradation or alteration before reaching the target tissue.

bioavailability

Clinical pharmacology The degree to which a drug is available to a target tissue after administration which, for oral drugs, reflects the rate and extent of GI tract absorption; BA is the in vivo presence of a substance in a form that allows it to be metabolized, serve as a substrate, bind a specific molecule, or participate in biochemical reactions. See Oral bioavailability.

bi·o·a·vail·a·bil·i·ty

(bī'ō-ă-vāl'ă-bil'i-tē) The physiologic availability of a given amount of a drug, as distinct from its chemical potency; proportion of the administered dose that becomes available to exert a pharmacologic effect into the bloodstream.

bioavailability

The amount of a drug that reaches the blood regardless of how it is given. After intravenous injection bioavailability is 100%, but the bioavailability of drugs given by mouth is often much less, because many drugs are broken down by the digestive enzymes and many are poorly absorbed.

Bioavailability

A measure of the amount of drug that is actually absorbed from a given dose.Mentioned in: Antiretroviral Drugs

bi·o·a·vail·a·bil·i·ty

(bī'ō-ă-vāl'ă-bil'i-tē) Physiologic availability of a given amount of a drug, as distinct from its chemical potency.

单词	bioavailability
释义	bioavailability bi·o·a·vail·a·bil·i·ty B0260400 (bī′ō-ə-vā′lə-bĭl′ĭ-tē)n. The degree to which or rate at which a drug or other substance is absorbed or becomes available at the site of physiological activity after administration. bi′o·a·vail′a·ble (-lə-bəl) adj. bioavailability (ˌbaɪəʊəˌveɪləˈbɪlɪtɪ) n (Medicine) the extent to which a drug or other substance is taken up by a specific tissue or organ after administration; the proportion of the dose of a drug that reaches the systemic circulation intact after administration by a route other than intravenous. Also called: systemic availability ˌbioaˈvailable adj bi•o•a•vail•a•bil•i•ty (ˌbaɪ oʊ əˌveɪ ləˈbɪl ɪ ti) n. the extent to which a substance can be used by the body. [1965–70] bi`o•a•vail′a•ble, adj. bioavailability bioavailability [‚bī·ō·ə‚vāl·ə′bil·əd·ē] (physiology) The extent and rate at which a substance, such as a drug, is absorbed into a living system or is made available at the site of physiological activity. bioavailability bioavailability [bi″o-ah-vāl″ah-bil´ĭ-te] the degree to which a drug or other substance becomes available to the target tissue after administration. bi·o·a·vail·a·bil·i·ty (bī'ō-ă-vāl'ă-bil'i-tē), The physiologic availability of a given amount of a drug, as distinct from its chemical potency; proportion of the administered dose that is absorbed into the bloodstream. bioavailability (bī′ō-ə-vā′lə-bĭl′ĭ-tē)n. The degree to which or rate at which a drug or other substance is absorbed or becomes available at the site of physiological activity after administration. bi′o·a·vail′a·ble (-lə-bəl) adj. bioavailability The rate and extent to which a drug is available to serve as a substrate, bind to a specific molecule or participate in biochemical reactions in a target tissue after administration. For oral agents, bioavailability reflects the rate and extent of GI tract absorption. Bioavailability depends on the pI (isoelectric point), the pH of a solution in which the solute does not migrate (ionic form), presence of side chains or the conformation of the epitope. Bioavailability is affected by the route of administration, rate of metabolism, lipid solubility and binding proteins. It is usually < 100% due to degradation or alteration before reaching the target tissue. bioavailability Clinical pharmacology The degree to which a drug is available to a target tissue after administration which, for oral drugs, reflects the rate and extent of GI tract absorption; BA is the in vivo presence of a substance in a form that allows it to be metabolized, serve as a substrate, bind a specific molecule, or participate in biochemical reactions. See Oral bioavailability. bi·o·a·vail·a·bil·i·ty (bī'ō-ă-vāl'ă-bil'i-tē) The physiologic availability of a given amount of a drug, as distinct from its chemical potency; proportion of the administered dose that becomes available to exert a pharmacologic effect into the bloodstream. bioavailability The amount of a drug that reaches the blood regardless of how it is given. After intravenous injection bioavailability is 100%, but the bioavailability of drugs given by mouth is often much less, because many drugs are broken down by the digestive enzymes and many are poorly absorbed. Bioavailability A measure of the amount of drug that is actually absorbed from a given dose.Mentioned in: Antiretroviral Drugs bi·o·a·vail·a·bil·i·ty (bī'ō-ă-vāl'ă-bil'i-tē) Physiologic availability of a given amount of a drug, as distinct from its chemical potency. AcronymsSeebarium
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