negative inotrope

negative inotropic agent

Any agent, including beta-blockers (e.g., metoprolol) or calcium channel blockers (e.g., diltiazem, verapamil), used to manage congestive heart failure caused by pure diastolic dysfunction, as such agents reduce cardiac contractility.

negative inotrope

Negative inotropic agent Cardiology Any agent–eg, β—blockers–eg, metoprolol or CCBs–eg, diltiazem, verapamil, used to manage CHF due to pure diastolic dysfunction, as they ↓ cardiac contractility