trimetrexate glucuronate

trimetrexate glucuronate

NeuTrexin® An antimetabolic lipophilic dihydrofolate reductase inhibitor–ie, antifolate structurally related to MTX, which is antineoplastic and antimicrobial; TG is approved for treating PCP when Bactrim/Septra cannot be used in immunocompromised Pts, and in Pts with colorectal, gastric, and pancreatic CA, acute leukemia, osteosarcoma; it may enhance 5-FU effectiveness in 5-FU and leucovorin-based therapy, improving survival. See Pneumocystis carinii pneumonia.