phosphatase

phos·pha·tase

P0256900 (fŏs′fə-tās′, -tāz′)n. Any of numerous enzymes that catalyze the removal of phosphate groups by hydrolysis of phosphate ester bonds. They act in the opposite manner to kinases and are important in metabolism and cell signaling.

[phosphat(e) + -ase.]

phosphatase

(ˈfɒsfəˌteɪs; -ˌteɪz) n (Biochemistry) any of a group of enzymes that catalyse the hydrolysis of organic phosphates

phos•pha•tase

(ˈfɒs fəˌteɪs, -ˌteɪz)

n. any of several classes of esterases of varying specificity that catalyze the hydrolysis of phosphoric esters.

Thesaurus

Noun

phosphatase - any of a group of enzymes that act as a catalyst in the hydrolysis of organic phosphatesenzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

Translations

fosfatasi

Phosphatase

enUK

phosphatase

[′fäs·fə‚tās] (biochemistry) An enzyme that catalyzes the hydrolysis and synthesis of phosphoric acid esters and the transfer of phosphate groups from phosphoric acid to other compounds.

Phosphatase

any of the enzymes of the hydrolase class that catalyze the hydrolysis of phosphoric acid esters in animals, plants, and microorganisms. Phosphatases maintain the phosphate level necessary for various biochemical processes; it may be that they also transport phosphate to the cell.

Depending on the chemical nature of the substrate, phosphatases are divided into monophosphatases, for example, glucose 6-phosphatase, which hydrolyze monoesters of phosphoric acid, and diphosphatases, such as nucleases, which break down the diesters of phosphoric acid. Monophosphatases, in turn, are classified as either specific (interacting with only one substrate) or nonspecific (having a wide range of activity). Depending on the nature of the medium in which their maximum activity is observed, nonspecific monophosphatases are referred to as either alkaline (optimal activity at pH 8–10) or acid (pH 4–6). Alkaline phosphatases are found in animal tissue (intestinal mucosa, placenta, kidneys, bones) and in milk, bacteria, and fungi; acid phosphatases are present in the tissue of the prostate gland, spleen, and liver and in yeasts, bacteria, and higher plants.

The most comprehensive studies have been carried out on the structure and mechanism of activity of the alkaline phosphatase in Escherichia coli. The enzyme is composed of two identical sub-units that function alternately; it contains firmly bonded Zn atoms and has a molecular weight of 80,000. The arrangement of the polypeptide chains is known, and it has been established that the reaction with the substrate passes through a stage of enzyme phosphorylation. A determination of the activity of acid and alkaline phosphatases is important in diagnosing diseases, such as rickets, that are accompanied by an increase in phosphatase activity.

REFERENCES

The Enzymes, 3rd ed., vol. 4. New York-London, 1971.

S. M. AVAEVA

phosphatase

[fos´fah-tās] any of a group of enzymes capable of catalyzing the hydrolysis of esterified phosphoric acid, with liberation of inorganic phosphate, found in practically all tissues, body fluids, and cells, including erythrocytes and leukocytes.acid phosphatase see acid phosphatase.alkaline phosphatase see alkaline phosphatase.

phos·pha·tase

(fos'fă-tās), Any of a group of enzymes (EC 3.1.3.x) that liberate orthophosphate from phosphoric esters.
See also: phosphohydrolases.

phosphatase

(fŏs′fə-tās′, -tāz′)n. Any of numerous enzymes that catalyze the removal of phosphate groups by hydrolysis of phosphate ester bonds. They act in the opposite manner to kinases and are important in metabolism and cell signaling.

phos·pha·tase

(fos'fă-tās) Any of a group of enzymes (EC sub-subclass 3.1.3) that liberate inorganic phosphate from phosphoric esters.

phosphatase

An enzyme that removes phosphate groups from a molecule.

phosphatase

an enzyme that catalyses the release of phosphate from a molecule. For example, in the mammalian liver phosphorylated glucose can be broken down to glucose with a phosphatase enzyme. see GLYCOGEN.

phos·pha·tase

(fos'fă-tās) Any of a group of enzymes (EC sub-subclass 3.1.3) that liberate inorganic phosphate from phosphoric esters.

phosphatase

phos·pha·tase

phosphatase

phos•pha•tase

Phosphatase

phosphatase

Phosphatase

REFERENCES

phosphatase

phosphatase

phos·pha·tase

phosphatase

phos·pha·tase

phosphatase

phosphatase

phos·pha·tase

phosphatase

Words related to phosphatase

noun any of a group of enzymes that act as a catalyst in the hydrolysis of organic phosphates

Related Words