villous atrophy


vil·lous at·ro·phy

abnormality of the small intestinal mucosa with crypt hyperplasia, resulting in flattening of the mucosa and the appearance of atrophy of villi; clinically seen in malabsorption syndromes such as sprue.

villous atrophy

Flattening and disappearance of the finger-like absorptive processes of the small intestine that is a feature of COELIAC DISEASE. Villous atrophy is associated with an increased density of LYMPHOCYTES in the bowel lining (intraepithelial lymphocytes), but whether they cause it is uncertain.