pyrimidine

enUK

py·rim·i·dine

P0686800 (pī-rĭm′ĭ-dēn′, pĭ-)n.1. A single-ringed, crystalline organic base, C₄H₄N₂, that is the parent compound of a large group of biologically important compounds.2. Any of a group of substituted derivatives of pyrimidine, including the nitrogen bases uracil, cytosine, and thymine, which are components of nucleic acids. Barbiturates and certain other drugs are also pyrimidines.

[Alteration of pyridine.]

pyrimidine

(paɪˈrɪmɪˌdiːn) n1. (Elements & Compounds) a liquid or crystalline organic compound with a penetrating odour; 1,3-diazine. It is a weakly basic soluble heterocyclic compound and can be prepared from barbituric acid. Formula: C4H4N22. (Elements & Compounds) Also called: pyrimidine base any of a number of similar compounds having a basic structure that is derived from pyrimidine, including cytosine, thymine, and uracil, which are constituents of nucleic acids[C20: variant of pyridine]

py•rim•i•dine

(paɪˈrɪm ɪˌdin, pɪ-)

n. 1. a heterocyclic compound, C₄H₄N₂, that is the basis of several important biochemical substances. 2. one of several pyrimidine derivatives, esp. the bases cytosine, thymine, and uracil, which are fundamental constituents of nucleic acids. [1880–85;b. pyridine and imide]

py·rim·i·dine

(pī-rĭm′ĭ-dēn′) Any of a group of organic compounds having a single ring with alternating carbon and nitrogen atoms. Pyrimidines include the bases cytosine, thymine, and uracil, which are components of nucleic acids.

Thesaurus

Noun	1.	pyrimidine - any of several basic compounds derived from pyrimidinealkali, base - any of various water-soluble compounds capable of turning litmus blue and reacting with an acid to form a salt and water; "bases include oxides and hydroxides of metals and ammonia"cytosine, C - a base found in DNA and RNA and derived from pyrimidine; pairs with guanineT, thymine - a base found in DNA (but not in RNA) and derived from pyrimidine; pairs with adenine
	2.	pyrimidine - a heterocyclic organic compound with a penetrating odororganic compound - any compound of carbon and another element or a radical

Translations

pyrimidine

enUK

pyrimidine

(pīrĭm`ĭdēn'), type of organic base found in certain coenzymescoenzyme
, any one of a group of relatively small organic molecules required for the catalytic function of certain enzymes. A coenzyme may either be attached by covalent bonds to a particular enzyme or exist freely in solution, but in either case it participates intimately in
..... Click the link for more information. and in the nucleic acidsnucleic acid,
any of a group of organic substances found in the chromosomes of living cells and viruses that play a central role in the storage and replication of hereditary information and in the expression of this information through protein synthesis.
..... Click the link for more information. of plant and animal tissue. The three major pyrimidines of almost universal distribution in living systems are cytosinecytosine
, organic base of the pyrimidine family. It was isolated from the nucleic acid of calf thymus tissue in 1894. A suggested structure for cytosine, published in 1903, was confirmed in the same year when that base was synthesized in the laboratory.
..... Click the link for more information. , thyminethymine
, organic base of the pyrimidine family. Thymine was the first pyrimidine to be purified from a natural source, having been isolated from calf thymus and beef spleen in 1893–4.
..... Click the link for more information. , and uraciluracil
, organic base of the pyrimidine family. It was isolated from herring sperm and also produced in a laboratory in 1900–1901. When combined with the sugar ribose in a glycosidic linkage, uracil forms a derivative called uridine (a nucleoside), which in turn can be
..... Click the link for more information. .

Pyrimidine

A heterocyclic organic (2) compound ( 1 ) containing nitrogen atoms at positions 1 and 3. Naturally occurring derivatives of the parent compound are of considerable biological importance as components of nucleic acids and coenzymes and, in addition, synthetic members of this group have found use as pharmaceuticals. See Coenzyme, Nucleic acid

Pyrimidine compounds which are found universally in living organisms include uracil ( 2 ), cytosine ( 3 ), and thymine (3) ( 4 ). Together with purines these substances make up the “bases” of nucleic acids, uracil and cytosine being found characteristically in ribonucleic acids, with thymine replacing uracil in deoxyribonucleic acids. A number of related pyrimidines also occur in lesser amounts in certain nucleic acids. Other pyrimidines of general natural occurrence are orotic acid and thiamine (vitamin B₁). See Deoxyribonucleic acid (DNA), Purine, Ribonucleic acid (RNA)

Among the sulfa drugs, the pyrimidine derivatives, sulfadi-azine, sulfamerazine, and sulfamethazine, have general formula ( 5 ). (4) These agents are inhibitors of folic acid biosynthesis in microorganisms. The barbiturates are pyrimidine derivatives which possess potent depressant action on the central nervous system.

Pyrimidine

(also called 1,3-diazine), a heterocyclic compound. Colorless crystals; melting point, 21°C; boiling point, 124°C. Pyrimidine is readily soluble in water, alcohol, and ether. The structural formula is

Pyrimidine is a very weak, monoacidic base that forms quaternary salts, each of which contains a single nitrogen atom; it also reacts with hydrogen peroxide (H₂O₂) to yield N-oxides. Pyrimidine does not enter readily into electrophilic substitution reactions, for example, halogenation, sulfonation, and nitration, but the hydrogen atom on the carbon in position number four is easily replaced in reactions with organomagnesium compounds, organolithium compounds, NaNH₂, and KOH. Pyrimidine is synthesized by reduction of its 2,4,6-trichloro derivative, which is a product of the reaction of POCI₃ with barbituric acid. Pyrimidine and its derivatives are components of individual nucleotides and of nucleic acids, the most important biopolymers. They also occur in many biologically active substances, including thiamine, the antibiotic, amicetin, and barbiturates.

pyrimidine

[pə′rim·ə‚dēn] (biochemistry) C₄H₄N₂ A heterocyclic organic compound containing nitrogen atoms at positions 1 and 3; naturally occurring derivatives are components of nucleic acids and coenzymes.

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py·rim·i·dine (Pyr),

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Words related to pyrimidine

noun any of several basic compounds derived from pyrimidine

Related Words

noun a heterocyclic organic compound with a penetrating odor

Related Words