waxy degeneration

am·y·loid de·gen·er·a·tion

infiltration of amyloid between cells and fibers of tissues and organs. Synonym(s): waxy degeneration (1)

amyloidosis

A large group of diseases characterised by misfolding of extracellular protein. Insoluble toxic proteins are deposited as bundles of β-sheet fibrillar protein, either in specific organs (localised amyloidosis) or systemically (systemic amyloidosis). It can be primary or secondary to other conditions (e.g., tuberculosis, cancer, leprosy) and accompanied by immune changes.
Primary amyloidosis (AL amyloidosis, idiopathic amyloidosis)
An uncommon condition associated with plasma cell dyscrasias, where the accumulated amyloid fibres correspond to fragments of Ig light chains.
Tissues involved
Heart, GI tract, nerves, skin, tongue, joints, muscle.
Median survival
20 months with renal or cardiac amyloidosis; 40 months without.

Secondary amyloidosis (AA amyloidosis, reactive amyloidosis)
A group of conditions seen in chronic inflammation and multisystem disease, in which amyloid derives from a circulating acute-phase lipoprotein (serum protein 1).

Tissues involved
Liver, spleen, kidney, endocrine, lymph nodes.
Both types of amyloidosis contain amyloid P component, a non-fibrillary glycoprotein found in the circulation; scintigraphy after injection of 123I-labelled serum amyloid P component can locate tissue deposition of amyloidosis and, if the deposition is active, cytotoxic therapy may be instituted; focal amyloidosis commonly occurs in those organs most susceptible to ageing (e.g., the heart and brain), and is only symptomatic if the amyloid deposition is significant.

am·y·loid de·gen·er·a·tion

(am'i-loyd dĕ-jen'ĕr-ā'shŭn) Infiltration of amyloid between cells and fibers of tissues and organs.
Synonym(s): waxy degeneration (1) .

Zen·ker de·gen·er·a·tion

(tsen'ker dĕ-jen'ĕr-ā'shŭn) A form of severe hyaline degeneration or necrosis in skeletal muscle, occurring in severe infections.
Synonym(s): waxy degeneration (2) .

Zenker,

Friedrich Albert von, German pathologist, 1825-1898. formol-Zenker fixative - Zenker fixative in which glacial acetic acid has been replaced by formalin.Zenker degeneration - a form of severe hyaline degeneration or necrosis in skeletal muscle, occurring in severe infections. Synonym(s): waxy degeneration; Zenker necrosisZenker diverticulum - common diverticulum of the esophagus, arises between the inferior pharyngeal constrictor and the cricopharyngeus muscle. Synonym(s): pharyngoesophageal diverticulumZenker fixative - a rapid fixative.Zenker necrosis - Synonym(s): Zenker degenerationZenker paralysis - paresthesia and paralysis in the area of the external popliteal nerve.

Waxy degeneration

waxy degeneration

am·y·loid de·gen·er·a·tion

amyloidosis

am·y·loid de·gen·er·a·tion

Zen·ker de·gen·er·a·tion

Zenker,