单词 |
x inactivation |
释义 |
X inactivation ly·on·i·za·tion (lī'on-i-zā'shŭn), The normal phenomenon that wherever there are two or more haploid sets of X-linked genes in each cell all but one of the genes are inactivated apparently at random and have no phenotypic expression. Lyonization is usual but not invariable for all loci. Its randomness explains the more variable espressivity of X-linked traits in women than in men. Lyonization occurs in men with the Klinefelter (XXY) karyotype. See also: gene dosage compensation. Synonym(s): Lyon hypothesis, X inactivation, X-inactivation [M. Lyon] X inactivationThe silencing of the genes on one of a woman's paired X chromosomes, allowing the other chromosome's genes to be expressed phenotypically. The process is not universal but affects 75% or more of the genes on the chromosome. Genes that are found near the short end of the chromosome are more likely than the rest to be expressed phenotypically, i.e., to escape inactivation. |
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