英语词汇“chemical carcinogenesis”的英英意思、用法、释义、翻译、读音、例句、短语、词组-英语词典

单词	chemical carcinogenesis
释义	DictionarySeecarcinogenesis chemical carcinogenesis chemical carcinogenesis [¦kem·i·kəl ‚kär·sə·nə′gen·ə·səs] (medicine) The chemical-induced cancerous transformation of normal cells via a multistep process in which the genetic code of the cells is altered and then the altered cells are promoted to form tumors. chemical carcinogenesis chemical carcinogenesis The induction of malignancy by a known or putative chemical carcinogen, which can be occupational (e.g., aromatic amines, arsenic, benzene, cadmium, chromium ores, soots, tars, vinyl chloride), environmental (e.g., aflatoxin, asbestos, tobacco) or iatrogenic (e.g., alkylating agents, anabolic steroids, phenacetin). Pathogenesis Initiation of the carcinogenic cascade occurs when an electrophilically reactive chemical (initiator) or, more often, one or more of its metabolites interacts with DNA, and repair of the damaged DNA is unsuccessful; this is followed by a sequence of events known as tumour promotion.
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