Carbonic Anhydrase

carbonic anhydrase

[kär′bän·ik an′hī‚drās] (biochemistry) An enzyme which aids carbon dioxide transport and release by catalyzing the synthesis, and the dehydration, of carbonic acid from, and to, carbon dioxide and water.

Carbonic Anhydrase

carboanhydrase, carbonate hydrolase, an enzyme of the lyase class that catalyzes the reversible formation of carbonic acid from carbon dioxide and water: CO₂ + H ₂O ⇄H₂CO₃.. Carbonicanhydrase is a metallo-protein containing zinc. Molecular weight, about 30, 000.

Carbonic anhydrase is found in erythrocytes and in cells of the kidneys, the gastric mucosa, and the retina of the eye. Erythrocytic carbonic anhydrase provides for the bonding of CO₂with blood in the tissues and for its rapid release in the lungs or branchia. Carbonic anhydrase makes for the formation of acid urine in the kidney, hydrochloric acid in the gastric mucosa, bicarbonates of pancreatic juice in the pancreas, and eggshells (containing CaCO₃) in the oviducts of birds. Carbonic anhydrase is specifically and strongly inhibited by sulfonamides, which contain an aromatic group. Diamox (acetazolamide), Pentazane (methazolamide), and other agents used in the treatment of glaucoma and diseases of the retina and nervous system are examples of especially active carbonic anhydrase inhibitors. Carbonic anhydrase also occurs in the leaves of certain plants.

E. IU. CHENYKAEVA

carbonic anhydrase

anhydrase

[an-hi´drās] an enzyme that catalyzes the removal of water from a compound.carbonic anhydrase an enzyme that catalyzes the decomposition of carbonic acid into carbon dioxide and water, facilitating transfer of carbon dioxide from tissues to blood and from blood to alveolar air.

car·bon·ic an·hy·drase

a zinc-containing enzyme that catalyzes the interconversion of CO₂ with HCO₃^- and H⁺. There are at least seven human isozymes that appear predominantly in red blood cells, secretory tissues, and muscle. A deficiency of carbonic anhydrase II can result in osteopetrosis and metabolic acidosis. The inhibition of carbonic anhydrase IV and possibly carbonic anhydrase II by sulfonamides is a current therapy in the treatment of glaucoma. Synonym(s): carbonate dehydratase, carbonate hydro-lyase

carbonic anhydrase

an enzyme that accelerates the reaction between carbon dioxide and water to form carbonic acid in the red blood cells.

单词	carbonic anhydrase
释义	carbonic anhydrase carbonic anhydrase n (Biochemistry) an enzyme in blood cells that catalyses the decomposition of carbonic acid into carbon dioxide and water, facilitating the transport of carbon dioxide from the tissues to the lungs Carbonic Anhydrase carbonic anhydrase [kär′bän·ik an′hī‚drās] (biochemistry) An enzyme which aids carbon dioxide transport and release by catalyzing the synthesis, and the dehydration, of carbonic acid from, and to, carbon dioxide and water. Carbonic Anhydrase carboanhydrase, carbonate hydrolase, an enzyme of the lyase class that catalyzes the reversible formation of carbonic acid from carbon dioxide and water: CO₂ + H ₂O ⇄H₂CO₃.. Carbonicanhydrase is a metallo-protein containing zinc. Molecular weight, about 30, 000. Carbonic anhydrase is found in erythrocytes and in cells of the kidneys, the gastric mucosa, and the retina of the eye. Erythrocytic carbonic anhydrase provides for the bonding of CO₂with blood in the tissues and for its rapid release in the lungs or branchia. Carbonic anhydrase makes for the formation of acid urine in the kidney, hydrochloric acid in the gastric mucosa, bicarbonates of pancreatic juice in the pancreas, and eggshells (containing CaCO₃) in the oviducts of birds. Carbonic anhydrase is specifically and strongly inhibited by sulfonamides, which contain an aromatic group. Diamox (acetazolamide), Pentazane (methazolamide), and other agents used in the treatment of glaucoma and diseases of the retina and nervous system are examples of especially active carbonic anhydrase inhibitors. Carbonic anhydrase also occurs in the leaves of certain plants. E. IU. CHENYKAEVA carbonic anhydrase anhydrase [an-hi´drās] an enzyme that catalyzes the removal of water from a compound.carbonic anhydrase an enzyme that catalyzes the decomposition of carbonic acid into carbon dioxide and water, facilitating transfer of carbon dioxide from tissues to blood and from blood to alveolar air. car·bon·ic an·hy·drase a zinc-containing enzyme that catalyzes the interconversion of CO₂ with HCO₃^- and H⁺. There are at least seven human isozymes that appear predominantly in red blood cells, secretory tissues, and muscle. A deficiency of carbonic anhydrase II can result in osteopetrosis and metabolic acidosis. The inhibition of carbonic anhydrase IV and possibly carbonic anhydrase II by sulfonamides is a current therapy in the treatment of glaucoma. Synonym(s): carbonate dehydratase, carbonate hydro-lyase carbonic anhydrase an enzyme that accelerates the reaction between carbon dioxide and water to form carbonic acid in the red blood cells. See COMSEC Account See CAHThesaurusSeecarbonic
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