DAX-1

Orphan nuclear receptor that participates in adrenal and hypothalamic organogenesis. Defective DAX-1 has been associated with X-linked adrenal insufficiency and hypogonadotropic hypogonadism.

DAX1

A gene (DSS-AHC critical region on the X chromosome, gene 1—formally known, per HUGO nomenclature, as NR0B1) located on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. DAX1 also acts as an anti-testis gene by antagonising SRY.
Molecular pathology
DAX1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.

单词	dax-1
释义	DAX-1 DAX-1 Orphan nuclear receptor that participates in adrenal and hypothalamic organogenesis. Defective DAX-1 has been associated with X-linked adrenal insufficiency and hypogonadotropic hypogonadism. DAX1 A gene (DSS-AHC critical region on the X chromosome, gene 1—formally known, per HUGO nomenclature, as NR0B1) located on chromosome Xp21.3 that encodes a protein containing a DNA-binding domain, which acts as a dominant-negative regulator of transcription mediated by the retinoic acid receptor. DAX1 also acts as an anti-testis gene by antagonising SRY. Molecular pathology DAX1 mutations cause both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
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