| 单词 | cul2 |
| 释义 | CUL2CUL2A gene on chromosome 10p11.21 that encodes cullin-2, a core protein of multiple cullin-RING-based ECS (elonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Cullin-2 may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The ubiquitin-protein ligase activity of the complex depends on neddylation of the cullin subunit, and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. |
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