| 单词 | hook effect |
| 释义 | hook effecthook effecthook effectA curvilinear artefact occasionally seen in the immunoradiometric assay (IRMA) which appears when the hormone being measured is present in very high concentrations. The detector system will not measure the excess, as it will have reached a theoretical limit; the decreased counts bound with the labelled antibody at high hormone levels result in a spuriously decreased result being reported. IRMA should not be used for measuring hormones that may be in high concentrations—hCG, prolactin, or gastrin in clinical samples. The hook effect requires the measurement of two different concentrations to establish linearity. |
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