单词	necrobiosis
释义	necrobiosis /ˌnɛkrə(ʊ)bʌɪˈəʊsɪs / noun [mass noun] Medicine Gradual degeneration and death of cells in the body tissues.Diabetic necrobiosis typically causes discrete pretibial plaques, not the confluent skin changes seen in this patient.... Apart from necrobiosis lipoidica, diabetes is not a primary cause of ulceration but often leads to ulceration through neuropathy or ischaemia, or both. Ulceration occurs in about one third of diabetic patients with necrobiosis lipoidica, and spontaneous remission is relatively uncommon. Derivatives necrobiotic /ˌnɛkrə(ʊ)bʌɪˈɒtɪk/ adjective ... Because necrobiotic nodules may be indistinguishable radiologically from carcinoma and infectious granulomas, it has been recommended that all pulmonary nodules in rheumatoid patients be biopsied. Acinar cells surrounding the necrotic foci showed atrophy and necrobiotic changes, and numerous eosinophilic intranuclear inclusions with clear halos (Cowdry type A) were noted. Despite the increased frequency of lung cancer in patients with rheumatoid lung disease, we could find only 2 previous case reports of a carcinoma occurring in intimate association with a necrobiotic nodule.
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