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单词 lactamase
释义 lactamase Biochem.|ˈlæktəmeɪz, -s|
[f. lactam + -ase.]
β-lactamase: any of the enzymes (produced by certain bacteria) which cause the breaking of the carbon-nitrogen bond in the lactam ring of penicillins and cephalosporins (so rendering them ineffective as antibiotics).
1964Jrnl. Gen. Microbiol. XXXVI. 206 Amidase-forming coliform organisms did not attack the 6-APA nucleus, whereas β-lactamase-forming coliform organisms opened the lactam ring.1971N. Citri in P. D. Boyer et al. Enzymes (ed. 3) IV. ii. 24 The role of penicillinase and other β-lactamases in conferring resistance to penicillins and the closely related cephalosporins has been amply demonstrated.
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