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单词 pronethalol
释义 pronethalol, n. Pharm.|prəʊˈnɛθəlɒl|
Also pronetalol |-ˈnɛt-|.
[f. propyl n. + naphthyl n. + ethanol n. + *-olol]
A beta-adrenoceptor blocking drug, 2-isopropylamino-1-(2-naphthyl)ethanol, C15H19NO , formerly used in the treatment of angina and cardiac dysrhythmias. Superseded by its structural derivative, propranolol.
1963Brit. Jrnl. Pharmacol. XXI. 63 The β-blocking agent pronethalol..significantly reduced the combined toxicity of yohimbine and imipramine.1964WHO Chron. XVIII. 439 Pronetalol.1972Materials & Technol. V. xxi. 810 Beta receptor blocking drugs such as propranolol and pronethalol find their application in the treatment of certain cardiac conditions.1987Molecular Pharmacol. XXXI. 101/2 Drugs with higher lipophilicity, such as exaprolol, Kö-1124, alprenolol, propranolol, metipranolol, doberol, and pronethalol, had a severalfold higher perturbation effect at the hydrocarbon membrane core than at the region close to the polar lipid part.
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