| 释义 |
macroglobulin Biochem.|mækrəʊˈglɒbjʊlɪn|
[ad. G. makroglobulin (attributed to Pedersen and Waldenström by Waldenström 1948, in Schweiz. Med. Wochenschr. 25 Sept. 928/2): see macro- b and globulin.]
Any of the immunoglobulins of very high molecular weight (about 1,000,000 or more).
1952J. Waldenström in Adv. Internal Med. V. 408 Pedersen compared this normally occurring macromolecule with the pathologic so-called ‘macroglobulin’ found in the disease described by us as macroglobulinemia. 1961[see macroglobulinæmia below]. 1967Times 21 Nov. 3/6 As well as these small antibody molecules, the body produces much larger antibodies, called macroglobulins.
So ˌmacroglobuliˈnæmia [ad. G. makroglobulinämie (J. Waldenström 1948, in Schweiz. Med. Wochenschr. 25 Sept. 928/2)], an excess of macroglobulins in the blood; esp. (more fully Waldenström's macroglobulinæmia or syndrome) a disease similar to myelomatosis but less often fatal; ˌmacroglobuliˈnæmic a.
1949K. Pedersen in Jrnl. Franklin Inst. CCXLVIII. 570 In a few rare cases of essential macroglobulinemia.., a very high concentration of the 20 S component has been found. 1961Lancet 5 Aug. 289/2 While there can be no doubt that Waldenström's syndrome exists, it seems that such increases in macroglobulins are not confined to a single disease entity. The term macroglobulinæmia will therefore be used in this paper to refer to the presence in the serum of increased amounts of macroglobulins, regardless of the clinical associations. Ibid. 290/1 On paper electrophoresis, macroglobulinæmic sera yield patterns which are indistinguishable from those found in multiple myeloma. 1971D. Hawkins in S. O. Freedman Clin. Immunol. vi. 179 Patients with Waldenstrom's [sic] macroglobulinemia may have proteinuria and even nephrotic syndrome. |