| 释义 |
mianserin, n. Pharm.|maɪˈænsərɪn|
[f. mian- + serotonin n.]
A tetracyclic compound, C18H20N2, with serotonin blocking properties, given orally (usually as the hydrochloride) in the treatment of depression.
1970Jrnl. Med. Chem. XIII. 36/1 Compound 5 (mianserin) proved to have..a less pronounced sedative effect and a lower acute toxicity as shown in pilot experiments on animals. 1983Stafford-Clark & Smith Psychiatry for Students (ed. 6) vii. 118 Mianserin (Norval, Bolvidon) has a kind of tetracyclic structure. 1986C. W. Thornber in C. A. Heaton Chem. Industry iv. 189 Further chemical modifications have led to variants such as mianserin..which has additional properties as a serotonin antagonist. 1989New Scientist 18 Mar. 31/2 The Committee on Safety of Medicines..declared that doctors' reports of adverse reactions in the blood to the antidepressant drug mianserin (Bolvidon) confirmed its own earlier warnings that the elderly are abnormally susceptible to these reactions. 1991Pulse 6 Apr. 74/4 The only other antidepressants which have been attended by any significant degree of success are mianserin, maprotiline, imipramine, and dothiepin. |