phenforminn.
/fɛnˈfɔːmɪn/, U.S. /fɛnˈfɔrm(ə)n/ Pharmacology.
A drug used in the oral treatment of diabetes mellitus (now largely withdrawn from use because of the side effect of lactic acidosis).Chemical name: 1-phenethylbiguanide, C10H15N5.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for diabetes
synthalin1927
protamine insulin1935
protamine zinc insulin1935
Ultralente1953
sulphonylurea1956
tolbutamide1956
phenformin1959
acetohexamide1961
metformin1961
tolazamide1963
1959 Canad. Med. Assoc. Jrnl. 80 773/1 In 1957 Ungar, Freedman and Shapiro reported that hypoglycæmic properties had been discovered in a synthetic diguanide compound, N′-β-phenethylformaminyliminourea hydrochloride, subsequently designated DB1 or phenformin.
1974 M. C. Gerald Pharmacol. xxv. 441 It appears that phenformin may act by accelerating the intracellular oxidation of glucose, a process which is depressed in the absence of insulin.
1977 Lancet 22 Jan. 191/2 Metformin is replacing phenformin as the biguanide of choice in the treatment of obese maturity-onset diabetics because of the association between phenformin therapy and lacticacidosis.
2003 Life Sci. 74 643 A large body of evidence suggests additional effects of phenformin including antitumoral activity in different animal models in vivo.
This entry has been updated (OED Third Edition, December 2005; most recently modified version published online March 2022).
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n.1959