probenecidn.
/prə(ʊ)ˈbɛnᵻsɪd/, U.S. /proʊˈbɛnəsəd/ Pharmacology.
A drug that increases the excretion of uric acid in the urine, used chiefly in the treatment of gout.Chemical name: p-(di-n-propylsulphamoyl)benzoic acid; (C3H7)2NSO2·C6H4COOH.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > cleansing or expelling medicines > [noun] > diuretic > uricosuric or saluretic
probenecid1950
sulphinpyrazone1958
saluretic1975
the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for arthritis, rheumatism, or gout > others
Portland powder1763
helmitol1903
probenecid1950
indomethacin1963
allopurinol1964
ibuprofen1967
naproxen1971
sulindac1975
1950 Ann. Internal Med. 33 18 Benemid. [Note] Sharp and Dohme's trademark for p-(di-n-propylsulfamyl)-benzoic acid. This drug has been tentatively given the generic designation ‘probenecid’.
1963 Lancet 5 Jan. 54/2 People with these vague aches associated with uric-acid blood-level elevation have responded well to colchicine intravenously as initial treatment and probenecid daily.
1974 A. Henry in R. M. Kirk et al. Surgery xv. 305 Acute attacks [of gout] are controlled by colchicine or phenylbutazone, while urico~suric agents such as probenecid keep the plasma uric level down and must be continued throughout life.
1999 Newsweek 15 Feb. 51/1 If you've been using too soon before your race, there are always ‘masking agents’. Probenecid, for one, inhibits substances from reaching the urine.
This entry has been updated (OED Third Edition, June 2007; most recently modified version published online March 2022).
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n.1950