Ghrelin, the endogenous growth hormone secretagogue, has an important role in metabolic homeostasis.
Darko M Stevanovic, Aldo Grefhorst, Axel P N Themmen, Vera Popovic, Joan Holstege,Elize Haasdijk, Vladimir Trajkovic, Aart-Jan van der Lely, Patric J D Delhanty 2014, 'Unacylated ghrelin suppresses ghrelin-induced neuronal activity in the hypothalamusand brainstem of male rats [corrected].', PLoS ONEhttp://europepmc.org/articles/PMC4031147?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Bicarbonate treatment reduced secretagogue-stimulated acinar cell vacuolization, an early marker of pancreatitis.
Thomas R. Kolodecik, Christine A. Shugrue, Edwin C. Thrower, Lonny R. Levin, JochenBuck, Fred S. Gorelick 2012, 'Activation of Soluble Adenylyl Cyclase Protects against Secretagogue Stimulated ZymogenActivation in Rat Pancreaic Acinar Cells', PLoS ONE10.1371/journal.pone.0041320. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ghrelin may modulate inflammatory signaling via growth hormone secretagogue receptors.
Yi-Ning Chao, David Sun, Yen-Chun Peng, Yuh-Lin Wu 2016, 'Growth Hormone Releasing Peptide-2 Attenuation of Protein Kinase C-Induced Inflammationin Human Ovarian Granulosa Cells', International Journal of Molecular Scienceshttp://www.mdpi.com/1422-0067/17/8/1359. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The peptide hormone ghrelin activates the growth hormone secretagogue receptor 1a, also known as the ghrelin receptor.
Gerrit Vortmeier, Stephanie H. DeLuca, Sylvia Els-Heindl, Constance Chollet, HolgerA. Scheidt, Annette G. Beck-Sickinger, Jens Meiler, Daniel Huster 2015, 'Integrating Solid-State NMR and Computational Modeling to Investigate the Structureand Dynamics of Membrane-Associated Ghrelin', PLOS ONE10.1371/journal.pone.0122444. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Secretagogue-induced degranulation and up-regulation of these genes was suppressed when cultured in the presence of dexamethasone.
Keiko Yamada, Hitomi Sato, Kazuma Sakamaki, Mayumi Kamada, Yasushi Okuno, NobuyukiFukuishi, Kazuyuki Furuta, Satoshi Tanaka 2019, 'Suppression of IgE-Independent Degranulation of Murine Connective Tissue-Type MastCells by Dexamethasone', Cellshttps://www.mdpi.com/2073-4409/8/2/112. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Some studies hinted at a connection between nesfatin-1 and the ghrelin receptor, growth hormone secretagogue receptor.
Xin-Tong Fan, Zhao Tian, Shi-Zhen Li, Ting Zhai, Jun-Li Liu, Rui Wang, Cai-Shun Zhang,Liu-Xin Wang, Jun-Hua Yuan, Yu Zhou, Jing Dong, Jing Dong 2018, 'Ghrelin Receptor Is Required for the Effect of Nesfatin-1 on Glucose Metabolism',Frontiers in Endocrinologyhttps://www.frontiersin.org/article/10.3389/fendo.2018.00633/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Ghrelin, a growth-hormone secretagogue, stimulates muscle anabolism, has anti-inflammatory effects, promotes vasodilation, and improves cardiac performance.
Nazareth de Novaes Rocha, Milena Vasconcellos de Oliveira, Cássia Lisboa Braga, GabrielaGuimarães, Lígia de Albuquerque Maia, Gisele de Araújo Padilha, Johnatas Dutra Silva,Christina Maeda Takiya, Vera Luiza Capelozzi, Pedro Leme Silva, Patricia Rieken MacedoRocco 2017, 'Ghrelin therapy improves lung and cardiovascular function in experimental emphysema',Respiratory Researchhttp://link.springer.com/article/10.1186/s12931-017-0668-9. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)