MANBA

MANBA

A gene on chromosome 4q22-q25 that encodes a member of the glycosyl hydrolase 2 family, which localises to the lysosome where it is the final exoglycosidase in the N-linked glycoprotein oligosaccharide catabolism pathway.
 
Molecular pathology
Defects in MANBA cause beta-mannosidosis.