| 释义 |
acanthosis nigricans
Thesaurus| Noun | 1. |  acanthosis nigricans - a skin disease characterized by dark wartlike patches in the body folds; can be benign or malignantkeratosis nigricansdisease of the skin, skin disease, skin disorder - a disease affecting the skin |
TranslationsEncyclopediaSeeacanthosisacanthosis nigricans
acanthosis [ak″an-tho´sis] diffuse hypertrophy or thickening of the prickle cell layer of the skin. adj., adj acanthot´ic.acanthosis ni´gricans diffuse acanthosis with gray, brown, or black pigmentation, chiefly in the axillae and other body folds, occurring in an adult form, often associated with an internal carcinoma (called malignant acanthosis nigricans) and in a benign, nevoid form, more or less generalized. A benign form associated with obesity, which is sometimes due to endocrine disturbance, is called pseudo-acanthosis nigricans. (See Atlas 2, Part E).ac·an·tho·sis ni·'gri·cans [MIM*100600] an eruption of velvety, warty benign growths and hyperpigmentation on the skin of the axillae, neck, anogenital area, and groin; in adults, may be associated with internal malignancy, endocrine disorders (characterized by insulin resistance), or obesity; seen in Type 2 diabetes in adolescents; a benign hereditary type occurs in children.
See also: pseudoacanthosis nigricans. [L. fr. niger, black] acanthosis nigricans (nī′grĭ-kănz′, nĭg′rĭ-)n. An eruption of velvety wartlike growths accompanied by hyperpigmentation in the skin of the axillae, neck, anogenital area, and groin, occurring in a benign form in children, but associated with internal malignancy or reticulosis in adults.acanthosis nigricans A condition characterised by dark, hyperkeratotic and papillomatous changes of the skin in body folds, including the axilla, groin, umbilicus, neck. It is associated with diabetes and internal malignancy, typically adenocarcinoma, especially of the GI tract and uterus. Treatment of the underlying condition usually results in resolution of the skin lesions.
Forms
• Malignant—associated with cancer (CA), e.g., gastric CA, but also rarely Hodgkin’s disease, or osteosarcoma.
• Inherited.
• Endocrine-related—Associated with pituitary tumours, polycystic ovary syndrome, insulin resistance, obesity.
• Idiopathic.
• Benign acanthosis nigricans (AN).
• AN associated with obesity.
• Syndromic AN.
• Malignant AN.
• Acral AN.
• Unilateral AN.
• Drug-induced AN.
• Mixed AN.acanthosis nigricans Dermatology A condition characterized by hyperkeratosis and papillomatosis Forms Malignant–associated with CA–eg, gastric CA, but also rarely Hodgkin's disease, or bone CA; inherited; endocrine–associated with pituitary tumors, polycystic ovary syndrome, insulin resistance, idiopathicac·an·tho·sis ni·gri·cans (ak-an-thō'sis nī'gri-kanz) An eruption of velvet warty benign growths and hyperpigmentation occurring in the skin of the axillae, neck, anogenital area, and groin; in adults, may be associated with internal malignancy, endocrine disorders, or obesity; a benign type occurs in children. [L. fr. niger, black]acanthosis nigricans Black or brown pigmented warty areas overlying patches of ACANTHOSIS. These occur in the armpits and other body folds and may sometimes be associated with ACROMEGALY, ADDISON'S DISEASE, POLYCYSTIC OVARY, intestinal CANCER or the INSULIN RESISTANCE SYNDROME.Acanthosis nigricansA dark brownish or blackish discoloration of the skin related to overweight and high levels of insulin in the blood. Acanthosis nigricans is most likely to develop in the groin or armpits, or around the back of the neck.Mentioned in: Insulin ResistanceMiescher, Alfred Guido, Swiss dermatologist, 1877-1961. Miescher cheilitis - Synonym(s): Melkersson-Rosenthal syndromeMiescher-Leder syndrome - reddish granulomatous plaques. Synonym(s): granuloma disciformis; necrobiosis maculosaMiescher I syndrome - benign velvety warty growths. Synonym(s): acanthosis nigricansMiescher II syndrome - inflammatory granulomas of the lips. Synonym(s): granulomatous cheilitisacanthosis nigricans A rare skin disorder presenting numerous superficial, pigmented papillomatous growths on various parts of the body. Ocular manifestations are primarily papillomatous lesions of the lid margins, which may be so extensive as to cause punctal occlusion, as well as papillary conjunctivitis. Syn. keratosis nigricans.ac·an·tho·sis ni·gri·cans (ak-an-thō'sis nī'gri-kanz) [MIM*100600] Eruption of velvety, warty benign growths and hyperpigmentation on the skin of the axillae, neck, anogenital area, and groin. [L. fr. niger, black]AcronymsSeeANacanthosis nigricans
Synonyms for acanthosis nigricansnoun a skin disease characterized by dark wartlike patches in the body foldsSynonymsRelated Words- disease of the skin
- skin disease
- skin disorder
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