bisphosphonate

diphosphonate

[di-fos´fo-nāt] any of a group of related phosphorus-containing compounds that are structurally similar to pyrophosphate but have enhanced stability to enzymatic and chemical hydrolysis and have affinity for sites of osteoid mineralization. They are used as sodium salts to inhibit bone resorption as well as complexed with technetium Tc 99m for bone imaging. The group includes alendronate, etidronate, and pamidronate. Called also bisphosphonate.

bisphosphonate

(bīs-fos-fō'nāt), Member of a class of drugs used for treatment of osteoporosis; works by inhibiting osteoclast-mediate resorption of bone.

bisphosphonate

(bĭs′fŏs′fə-nāt′)n. Any of a class of drugs that decrease bone resorption by inhibiting osteoclasts, used in the treatment of osteoporosis, Paget's disease, bone metastases, and other conditions. Also called diphosphonate.

bisphosphonate

Any of a family of drugs with two phosphonate (PO3) groups, which inhibit enzymes that break down pyrophosphate. Bisphosphonates include etidronate and clodronate (first-generation agents), and pamidronate disodium (a second-generation bisphosphonate), which inhibits bone resorption at doses that do not affect bone mineralisation. Bisphosphonates are potent inhibitors of bone resorption that bind tightly to the hydroxyapatite crystals, and have therapeutic potential in osteoporosis and in advanced (stage-III) multiple myeloma and Paget’s disease of bone.
Indications
Treat and prevent osteoporosis, osteolysis due to metastatic breast and prostate cancer, multiple myeloma, Paget's disease of bone, fibrous dysplasia, Gaucher's disease, etc.
Adverse effect
Upset stomach, gastritis, oesophageal erosions; long-term effects include femoral fractures and an increased risk of oesophageal cancer.
Agents
Etidronate, clodronate, tiludronate.

Bisphosphonate

A class of drugs used to treat Paget's disease. These drugs bind to the minerals in bone tissue and lessen the amount of bone loss associated with Paget's disease.Mentioned in: Paget's Disease of Bone

bis·phos·pho·nate

(bī-fosfŏ-nāt) Member of a class of drugs used for treatment of osteoporosis; works by inhibiting osteoclast-mediate resorption of bone. bisphosphonate

单词	bisphosphonate
释义	bisphosphonate bis·phos·pho·nate B5288950 (bĭs′fŏs′fə-nāt′)n. Any of a class of drugs that decrease bone resorption by inhibiting osteoclasts, used in the treatment of osteoporosis, Paget's disease, bone metastases, and other conditions. Also called diphosphonate. [bis- + phosphon(ic acid), phosphorous acid (from phosphonium) + -ate.] bisphosphonate (ˌbɪsˈfɒsfəneɪt) n (Pharmacology) any drug of a class that inhibits the resorption of bone; used in treating certain bone disorders, esp osteoporosis Translations bisphosphonate diphosphonate [di-fos´fo-nāt] any of a group of related phosphorus-containing compounds that are structurally similar to pyrophosphate but have enhanced stability to enzymatic and chemical hydrolysis and have affinity for sites of osteoid mineralization. They are used as sodium salts to inhibit bone resorption as well as complexed with technetium Tc 99m for bone imaging. The group includes alendronate, etidronate, and pamidronate. Called also bisphosphonate. bisphosphonate (bīs-fos-fō'nāt), Member of a class of drugs used for treatment of osteoporosis; works by inhibiting osteoclast-mediate resorption of bone. bisphosphonate (bĭs′fŏs′fə-nāt′)n. Any of a class of drugs that decrease bone resorption by inhibiting osteoclasts, used in the treatment of osteoporosis, Paget's disease, bone metastases, and other conditions. Also called diphosphonate. bisphosphonate Any of a family of drugs with two phosphonate (PO3) groups, which inhibit enzymes that break down pyrophosphate. Bisphosphonates include etidronate and clodronate (first-generation agents), and pamidronate disodium (a second-generation bisphosphonate), which inhibits bone resorption at doses that do not affect bone mineralisation. Bisphosphonates are potent inhibitors of bone resorption that bind tightly to the hydroxyapatite crystals, and have therapeutic potential in osteoporosis and in advanced (stage-III) multiple myeloma and Paget’s disease of bone. Indications Treat and prevent osteoporosis, osteolysis due to metastatic breast and prostate cancer, multiple myeloma, Paget's disease of bone, fibrous dysplasia, Gaucher's disease, etc. Adverse effect Upset stomach, gastritis, oesophageal erosions; long-term effects include femoral fractures and an increased risk of oesophageal cancer. Agents Etidronate, clodronate, tiludronate. Bisphosphonate A class of drugs used to treat Paget's disease. These drugs bind to the minerals in bone tissue and lessen the amount of bone loss associated with Paget's disease.Mentioned in: Paget's Disease of Bone bis·phos·pho·nate (bī-fosfŏ-nāt) Member of a class of drugs used for treatment of osteoporosis; works by inhibiting osteoclast-mediate resorption of bone. bisphosphonate
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