an enzyme that can catalyse the union of two large molecules
Also called: ligase
synthetase in American English
(ˈsɪnθəˌteɪs; ˈsɪnthəˌteɪz)
noun
ligase
synthetase in American English
(ˈsɪnθəˌteis, -ˌteiz)
noun
Biochemistry
ligase
Word origin
[1947; synthet(ic) + -ase]-ase is a suffix used in the names of enzymes. Other words that use the affix -ase include: amylase, hyaluronidase, ligase, reverse transcriptase, transferase
Examples of 'synthetase' in a sentence
synthetase
Ethanol exacerbated the effects of hexachlorobenzene, among others, on the rate-limiting enzyme delta-aminolevulinatesynthetase.
M.C. Ríos de Molina, M.B. Mazzetti, M. Galigniana, C. Aldonatti, J.M. Tomio, L.C.San Martín de Viale 2002, 'The decrease in uroporphyrinogen decarboxylase activity induced by ethanol predisposesrats to the development of porphyria and accelerates xenobiotic-triggered porphyria,regardless of hepatic damage', Brazilian Journal of Medical and Biological Researchhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100004. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Both the glutamine synthetase and β-tubulin genes contained a complex set of polymorphisms.
Geun-Hye Gang, Hyun Ji Cho, Hye Sun Kim, Yong-Bum Kwack, Youn-Sig Kwak 2015, 'Analysis of Fungicide Sensitivity and Genetic Diversity among Colletotrichum Speciesin Sweet Persimmon', The Plant Pathology Journalhttp://www.ncbi.nlm.nih.gov/pmc/articles/4453992. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
We present an in vitro biochemical characterization of cereulide synthetase.
Diego A. Alonzo, Nathan A. Magarvey, T. Martin Schmeing 2015, 'Characterization of Cereulide Synthetase, a Toxin-Producing Macromolecular Machine',PLOS ONE10.1371/journal.pone.0128569. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The selected strains were found to have polyketide synthase and non-ribosomal peptide synthetase systems.
Meeta Masand, Kunjukrishnan Kamalakshi Sivakala, Ekta Menghani, Thangathurai Thinesh,Rangasamy Anandham, Gaurav Sharma, Natesan Sivakumar, Solomon R. D. Jebakumar, PolpassArul Jose 2018, 'Biosynthetic Potential of Bioactive Streptomycetes Isolated From Arid Region of theThar Desert, Rajasthan (India)', Frontiers in Microbiologyhttp://journal.frontiersin.org/article/10.3389/fmicb.2018.00687/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Glycogen synthetase-α gene expression was evaluated in the soleus muscle.
Frollini Anelena B, Prestes Jonato, Donatto Felipe F, Palanch Adrianne C, VerlengiaRozangela, Cavaglieri Claudia 2010, 'Effect of oat bran on time to exhaustion, glycogen content and serum cytokine profilefollowing exhaustive exercise', Journal of the International Society of Sports Nutritionhttp://www.jissn.com/content/7/1/32. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In this study, mutants are used to search for synthetase or hydrolase specific regulation.
Llorenç Fernández-Coll, Michael Cashel 2018, 'Contributions of SpoT Hydrolase, SpoT Synthetase, and RelA Synthetase to Carbon SourceDiauxic Growth Transitions in Escherichia coli', Frontiers in Microbiologyhttps://www.frontiersin.org/article/10.3389/fmicb.2018.01802/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Surprisingly, dihydrofolate reductase and dihydropteroate synthetase mutation prevalence did not enter the model.
Little Francesca, Distiller Greg B, Barnes Karen I 2010, 'Nonlinear mixed effects modeling of gametocyte carriage in patients with uncomplicatedmalaria', Malaria Journalhttp://www.malariajournal.com/content/9/1/60. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Prenatal diagnosis has been preformed in glutathione synthetase deficiency.
Larsson Agne, Ristoff Ellinor 2007, 'Inborn errors in the metabolism of glutathione', Orphanet Journal of Rare Diseaseshttp://www.OJRD.com/content/2/1/16. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Direct aldosterone synthetase antagonists represent a promising future therapy.
Vishal Gupta 2011, 'Mineralocorticoid hypertension', Indian Journal of Endocrinology and Metabolismhttp://www.ijem.in/article.asp?issn=2230-8210;year=2011;volume=15;issue=8;spage=298;epage=312;aulast=Gupta. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)