Lynch syndrome

(linch), type I, familial colorectal cancer, generally occurring at an early age; type II, familial colorectal cancer occurring at an early age in conjunction with female genital cancer or cancers at other sites proximal to the bowel.

Lynch syn·drome

(linch sin'drōm) Type I, familial colorectal cancer, generally occurring at an early age; type II, familial colorectal cancer occurring at an early age in conjunction with female genital cancer or cancers at other sites proximal to the bowel.

Lynch syndrome

(lĭnch) An autosomal dominant predisposition to colon cancer and other solid tumors. People with Lynch I syndrome are susceptible to colon cancer alone, whereas those with Lynch II syndrome have an additional tendency to get cancers of the colon, ovaries, breasts, and/or uterus. It is also known as hereditary nonpolyposis colorectal cancer.

Lynch syndrome

Hereditary non-polyposis colorectal cancer, a strong familial tendency to this class of cancers resulting from germ-line mutations in the DNA mismatch-repair genes MLH1, MSH2, MSH6 and PMS2. Three to four percent of all colorectal cancers involve the Lynch syndrome. Affected people are liable to develop cancers at an earlier age than average—around age 45—and most show evidence of MICROSATELLITE INSTABILITY.

单词	lynch syndrome
释义	Lynch syndrome Lynch syndrome (linch), type I, familial colorectal cancer, generally occurring at an early age; type II, familial colorectal cancer occurring at an early age in conjunction with female genital cancer or cancers at other sites proximal to the bowel. Lynch syn·drome (linch sin'drōm) Type I, familial colorectal cancer, generally occurring at an early age; type II, familial colorectal cancer occurring at an early age in conjunction with female genital cancer or cancers at other sites proximal to the bowel. Lynch syndrome (lĭnch) An autosomal dominant predisposition to colon cancer and other solid tumors. People with Lynch I syndrome are susceptible to colon cancer alone, whereas those with Lynch II syndrome have an additional tendency to get cancers of the colon, ovaries, breasts, and/or uterus. It is also known as hereditary nonpolyposis colorectal cancer. Lynch syndrome Hereditary non-polyposis colorectal cancer, a strong familial tendency to this class of cancers resulting from germ-line mutations in the DNA mismatch-repair genes MLH1, MSH2, MSH6 and PMS2. Three to four percent of all colorectal cancers involve the Lynch syndrome. Affected people are liable to develop cancers at an earlier age than average—around age 45—and most show evidence of MICROSATELLITE INSTABILITY.
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