intransitive. To stay in one place, esp. for too long. (In past participle in quot.)

To weary (oneself) with seeking.

transitive. To exhaust or fatigue with excessive watching; to weary by keeping from sleep. Frequently reflexive. Now archaic and rare.

transitive. To harass or worry (a person); to bother, pester, hassle. In later use colloquial or English regional.

With on or upon. Of a circumstance: to affect (a person) adversely; to fatigue or debilitate. Cf. weigh, v.1 22a.

transitive. To wear out by nagging or by persistent irritation. rare.

transitive. To induce a condition of fatigue in (a muscle, organ, etc.): see fatigue, n. 1c.

Originally U.S. to run into the ground: (a) to carry (a thing) to excess, to overdo; (b) to destroy or damage beyond repair by excessive use, to…