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holo-enzyme
holo-enzyme n. 
/ˈhɒləʊˌɛnzʌɪm/, /ˈhɑloʊˌɛnˌzaɪm/, /ˌhoʊloʊˈɛnˌzaɪm/, /ˈhoʊloʊˌɛnˌzaɪm/ [ < French holoenzyme ( Compt. Rend. XIIme Conf. Union Internat. de Chim. 43)] Biochemistry the active form of an enzyme, consisting of the apo-enzyme combined with its co-enzyme.
Brit. /ˌhɒləʊˈɛnzʌɪm/
, /ˌhɒləʊˈɛnzʌɪm//ˈhɒləʊˌɛnzʌɪm/U.S. /ˌhɑloʊˈɛnˌzaɪm/
, /ˌhɑloʊˈɛnˌzaɪm//ˈhɑloʊˌɛnˌzaɪm//ˌhoʊloʊˈɛnˌzaɪm//ˈhoʊloʊˌɛnˌzaɪm/ΚΠ
1943 J. B. Sumner & G. F. Somers Chem. & Methods of Enzymes i. 32 A few examples of coenzymes and holoenzymes are given in Table 11.
1950 Endeavour 9 145/1 The entire enzyme or holoenzyme is built up of at least two fractions: (a) The apoenzyme, which is always a protein; it is colloidal and thermolabile. (b) The co-enzyme, of variable chemical constitution, frequently a phosphoric ester and sometimes a metallic derivative; very often the co-enzyme, which is non-colloidal, is fairly thermostable.
1971 Nature 15 Oct. 478/2 The rate of production of active holoenzyme from apoenzyme is enhanced by tryptophan about ten-fold.
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