In various phrases. to kill one's heart: to depress or discourage one completely. Obsolete.

To prostrate mentally; in weaker sense, to shock, depress. Obsolete except in to strike all of (†on) a heap (colloquial): see heap, n. 5e.

transitive. To overwhelm, crush.

To wreck (a person's constitution, nerves, etc.) by sickness, hardship, or the like. Also, to wreck the health, strength, or spirits of (a person).